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Review
. 2023 Jun 13;24(12):10079.
doi: 10.3390/ijms241210079.

The Role of EMT-Related lncRNAs in Ovarian Cancer

Dimitra Ioanna Lampropoulou  1 , Marios Papadimitriou  2   3 , Christos Papadimitriou  3 , Dimitrios Filippou  4   5 , Georgia Kourlaba  6 , Gerasimos Aravantinos  7 , Maria Gazouli  8
Affiliations
Review

The Role of EMT-Related lncRNAs in Ovarian Cancer

Dimitra Ioanna Lampropoulou et al. Int J Mol Sci. .

Abstract

Ovarian cancer (OC) is one of the deadliest cancers worldwide; late diagnosis and drug resistance are two major factors often responsible for high morbidity and treatment failure. Epithelial-to-mesenchymal transition (EMT) is a dynamic process that has been closely linked with cancer. Long non-coding RNAs (lncRNAs) have been also associated with several cancer-related mechanisms, including EMT. We conducted a literature search in the PubMed database in order to sum up and discuss the role of lncRNAs in regulating OC-related EMT and their underlying mechanisms. Seventy (70) original research articles were identified, as of 23 April 2023. Our review concluded that the dysregulation of lncRNAs is highly associated with EMT-mediated OC progression. A comprehensive understanding of lncRNAs' mechanisms in OC will help in identifying novel and sensitive biomarkers and therapeutic targets for this malignancy.

Keywords: EMT; biomarkers; lncRNAs; ovarian cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The crosstalk between non-coding RNAs and EMT. NcRNAs can act as oncogenes or tumor suppressors, regulating genes that modulate cell cycle-associated pathways and thus promoting or inhibiting the EMT process.
Figure 2
Figure 2
Proposed molecular mechanisms of identified oncogenic EMT-related lncRNAs in ovarian cancer.
Figure 3
Figure 3
Proposed molecular mechanisms of identified tumor-suppressing EMT-related lncRNAs in ovarian cancer.
See this image and copyright information in PMC

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