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Review
. 2023 Jun 20;24(12):10401.
doi: 10.3390/ijms241210401.

Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia

Anna Orzeł  1 , Katarzyna Unrug-Bielawska  2 , Dagmara Filipecka-Tyczka  1 , Krzysztof Berbeka  1 , Natalia Zeber-Lubecka  2   3 , Małgorzata Zielińska  1 , Anna Kajdy  1
Affiliations
Review

Molecular Pathways of Altered Brain Development in Fetuses Exposed to Hypoxia

Anna Orzeł et al. Int J Mol Sci. .

Abstract

Perinatal hypoxia is a major cause of neurodevelopmental impairment and subsequent motor and cognitive dysfunctions; it is associated with fetal growth restriction and uteroplacental dysfunction during pregnancy. This review aims to present the current knowledge on brain development resulting from perinatal asphyxia, including the causes, symptoms, and means of predicting the degree of brain damage. Furthermore, this review discusses the specificity of brain development in the growth-restricted fetus and how it is replicated and studied in animal models. Finally, this review aims at identifying the least understood and missing molecular pathways of abnormal brain development, especially with respect to potential treatment intervention.

Keywords: animal models; fetus growth restriction; perinatal hypoxia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Sarnat clinical staging of HIE based on [15].
Figure 2
Figure 2
FGR neuropathology. White matter and great matter pathology with the functional deficits indicated based on [20,22].
See this image and copyright information in PMC

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