Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 15;12(12):4062.
doi: 10.3390/jcm12124062.

Varicocele: To Treat or Not to Treat?

Affiliations
Review

Varicocele: To Treat or Not to Treat?

Antonio Franco et al. J Clin Med. .

Abstract

Varicocele treatment in infertility still remains controversial. It is clear, in fact, that in many patients, varicocele has no impact on fertility. Recent scientific evidence demonstrated that varicocele treatment is beneficial in improving semen parameters and pregnancy rate when an appropriate selection of patients is made. The purpose of treating varicocele in adults is mainly to improve current fertility status. On the other hand, the goal of treatment in adolescents is to prevent testicular injury and maintain testicular function for future fertility. Hence, the key to the success of varicocele treatment seems to be a correct indication. The aim of this study is to review and summarize current evidence in managing varicocele treatment focusing on the controversies regarding surgical indications in adolescent and adult patients, and in other specific situations such as azoospermia, bilateral or subclinical varicocele, and prior to ART.

Keywords: ART; infertility; varicocele repair; varicocelectomy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Microsurgical lymphatic sparing Palomo technique (arrow: spared lymphatics).
Figure 2
Figure 2
Flow chart analyzing indications to treat varicocele or perform ART.

References

    1. Franco G., Iori F., De Dominicis C., Dal Forno S., Mander A., Laurenti C. Challenging the Role of Cremasteric Reflux in the Pathogenesis of Varicocele Using a New Venographic Approach. J. Urol. 1999;161:117–121. doi: 10.1016/S0022-5347(01)62080-9. - DOI - PubMed
    1. Alsaikhan B., Alrabeeah K., Delouya G., Zini A. Epidemiology of Varicocele. Asian J. Androl. 2016;18:179. - PMC - PubMed
    1. Dubin L., Amelar R.D. Varicocele Size and Results of Varicocelectomy in Selected Subfertile Men with Varicocele. Fertil. Steril. 1970;21:606–609. doi: 10.1016/S0015-0282(16)37684-1. - DOI - PubMed
    1. Freeman S., Bertolotto M., Richenberg J., Belfield J., Dogra V., Huang D.Y., Lotti F., Markiet K., Nikolic O., Ramanathan S., et al. Ultrasound Evaluation of Varicoceles: Guidelines and Recommendations of the European Society of Urogenital Radiology Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for Detection, Classification, and Grading. Eur. Radiol. 2020;30:11–25. doi: 10.1007/s00330-019-06280-y. - DOI - PubMed
    1. WHO Manual for the Standardized Investigation and Diagnosis of the Infertile Male. [(accessed on 15 May 2023)]. Available online: https://www.who.int/publications/i/item/9780521774741.

LinkOut - more resources