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Review
. 2023 Jun 15;11(6):1589.
doi: 10.3390/microorganisms11061589.

Severe Combined Immunodeficiency-Classification, Microbiology Association and Treatment

Angel A Justiz-Vaillant  1 , Darren Gopaul  2 , Patrick Eberechi Akpaka  1   3 , Sachin Soodeen  1 , Rodolfo Arozarena Fundora  3   4
Affiliations
Review

Severe Combined Immunodeficiency-Classification, Microbiology Association and Treatment

Angel A Justiz-Vaillant et al. Microorganisms. .

Abstract

Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Autosomal, X-linked, and sporadic forms exist. Evidence of recurrent opportunistic infections and lymphopenia very early in life should prompt immunological investigation and suspicion of this rare disorder. Adequate stem cell transplantation is the treatment of choice. This review aimed to provide a comprehensive approach to the microorganisms associated with severe combined immunodeficiency (SCID) and its management. We describe SCID as a syndrome and summarize the different microorganisms that affect children and how they can be investigated and treated.

Keywords: HST; antibiotics; antifungals; infectious diseases; management; microorganisms; severe combined immunodeficiency.

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Conflict of interest statement

The authors declare no conflict of interest.

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