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Review
. 2023 May 26;12(6):766.
doi: 10.3390/pathogens12060766.

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia-A Literature Review

Adrian Boicean  1   2 , Dan Bratu  1   2 , Ciprian Bacila  2 , Ciprian Tanasescu  1   2 , Radu Sorin Fleacă  1   2 , Calin Ilie Mohor  1   2 , Andra Comaniciu  1 , Teodora Băluță  1 , Mihai Dan Roman  1   2 , Radu Chicea  1   2 , Adrian Nicolae Cristian  1   2 , Adrian Hasegan  1   2 , Sabrina Birsan  1   2 , Horațiu Dura  1   2 , Cosmin Ioan Mohor  1   2
Affiliations
Review

Therapeutic Perspectives for Microbiota Transplantation in Digestive Diseases and Neoplasia-A Literature Review

Adrian Boicean et al. Pathogens. .

Abstract

In a mutually beneficial connection with its host, the gut microbiota affects the host's nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.

Keywords: Clostridium difficile; cancer; extra-digestive diseases; fecal microbiota transplantation; melanoma.

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Conflict of interest statement

The authors declare no conflict of interest.

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