Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 18;12(6):840.
doi: 10.3390/pathogens12060840.

What about the Cytoskeletal and Related Proteins of Tapeworms in the Host's Immune Response? An Integrative Overview

Diana G Ríos-Valencia  1 , Javier Ambrosio  1 , Rocío Tirado-Mendoza  1 , Julio César Carrero  2 , Juan Pedro Laclette  2
Affiliations
Review

What about the Cytoskeletal and Related Proteins of Tapeworms in the Host's Immune Response? An Integrative Overview

Diana G Ríos-Valencia et al. Pathogens. .

Abstract

Recent advances have increased our understanding of the molecular machinery in the cytoskeleton of mammalian cells, in contrast to the case of tapeworm parasites, where cytoskeleton remains poorly characterized. The pertinence of a better knowledge of the tapeworm cytoskeleton is linked to the medical importance of these parasitic diseases in humans and animal stock. Moreover, its study could offer new possibilities for the development of more effective anti-parasitic drugs, as well as better strategies for their surveillance, prevention, and control. In the present review, we compile the results of recent experiments on the cytoskeleton of these parasites and analyze how these novel findings might trigger the development of new drugs or the redesign of those currently used in addition to supporting their use as biomarkers in cutting-edge diagnostic tests.

Keywords: Cestoda; cytoskeleton; diagnosis; drug targets; tapeworm; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Architecture of cytoskeleton.
Figure 2
Figure 2
Main locations of cytoskeleton proteins in tapeworms.
Figure 3
Figure 3
Diagnostic methods used to detect tapeworm infections.
See this image and copyright information in PMC

References

    1. Martínez-González J.D.J., Guevara-Flores A., del Arenal Mena I.P. Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions. Antioxidants. 2022;11:1102. doi: 10.3390/antiox11061102. - DOI - PMC - PubMed
    1. Bobes R.J., Fragoso G., Fleury A., García-varela M., Sciutto E., Larralde C., Laclette J.P. molecular epidemiology and perspectives on the research of taeniid parasites with special emphasis on Taenia solium. Infect. Genet. Evol. 2014;23:150–160. doi: 10.1016/j.meegid.2014.02.005. - DOI - PubMed
    1. Budke C.M., White A.C., Garcia H.H. Zoonotic Larval Cestode Infections: Neglected, Neglected Tropical Diseases? PLoS Negl. Trop. Dis. 2009;3:e319. doi: 10.1371/journal.pntd.0000319. - DOI - PMC - PubMed
    1. Torgerson P.R., Devleesschauwer B., Praet N., Speybroeck N., Willingham A.L., Kasuga F., Rokni M.B., Zhou X.-N., Fèvre E.M., Sripa B., et al. World Health Organization Estimates of the Global and Regional Disease Burden of 11 foodborne parasitic diseases, 2010: A Data Synthesis. PLoS Med. 2015;12:e1001920. doi: 10.1371/journal.pmed.1001920. - DOI - PMC - PubMed
    1. Dalton J.P., Skelly P., Halton D.W. Role of the tegument and gut in nutrient uptake by parasitic platyhelminths 1. J. Zool. 2004;82:211–232. doi: 10.1139/z03-213. - DOI

LinkOut - more resources