Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 30;16(6):817.
doi: 10.3390/ph16060817.

Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Dmitri Atiakshin  1   2 , Andrey Kostin  1 , Artem Volodkin  1 , Anna Nazarova  1 , Viktoriya Shishkina  2 , Dmitry Esaulenko  2 , Igor Buchwalow  1   3 , Markus Tiemann  3 , Mami Noda  4
Affiliations
Review

Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Dmitri Atiakshin et al. Pharmaceuticals (Basel). .

Abstract

Knowledge of the biological effects of molecular hydrogen (H2), hydrogen gas, is constantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effects of H2 are still being actively debated. In this review, we focus on mast cells as a potential target for H2 at the specific tissue microenvironment level. H2 regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H2 and offers great opportunities for translating the obtained findings into clinical practice.

Keywords: inflammation; local tissue microenvironment; mast cells; molecular hydrogen; reactive oxygen intermediates; secretome; specific mast cell proteases.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Targets for Mast Cell Secretome Components in a Specific Tissue Microenvironment. The figure shows the main targets of the specific tissue microenvironment for mast cells, including non-immune cells, immunocompetent cells and extracellular matrix targets. The arsenal of biologically active substances of MC for secretion is represented by a wide range of preformed, neoformed and neosynthesized mediators, which allows for the highly selective regulation of the state of cellular and extracellular targets within the determined physiological constants. Thus, by influencing the biosynthetic and secretory activities of mast cells, molecular hydrogen is able to indirectly regulate the key parameters of the local microenvironment within limited tissue compartments and niches.
Figure 2
Figure 2
Possible mechanisms of H2 regulation on the secretory pathways of pro-inflammatory mast cell mediators.
See this image and copyright information in PMC

References

    1. Albano G.D., Gagliardo R.P., Montalbano A.M., Profita M. Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases. Antioxidants. 2022;11:2237. doi: 10.3390/antiox11112237. - DOI - PMC - PubMed
    1. Batty M., Bennett M.R., Yu E. The Role of Oxidative Stress in Atherosclerosis. Cells. 2022;11:3843. doi: 10.3390/cells11233843. - DOI - PMC - PubMed
    1. Resiere D., Mehdaoui H., Neviere R. Inflammation and Oxidative Stress in Snakebite Envenomation: A Brief Descriptive Review and Clinical Implications. Toxins. 2022;14:802. doi: 10.3390/toxins14110802. - DOI - PMC - PubMed
    1. De Almeida A., de Oliveira J., da Silva Pontes L.V., de Souza Junior J.F., Goncalves T.A.F., Dantas S.H., de Almeida Feitosa M.S., Silva A.O., de Medeiros I.A. ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways. Oxid. Med. Cell. Longev. 2022;2022:1225578. doi: 10.1155/2022/1225578. - DOI - PMC - PubMed
    1. Villarreal-Garcia V., Estupinan-Jimenez J.R., Vivas-Mejia P.E., Gonzalez-Villasana V., Vazquez-Guillen J.M., Resendez-Perez D. A vicious circle in breast cancer: The interplay between inflammation, reactive oxygen species, and microRNAs. Front. Oncol. 2022;12:980694. doi: 10.3389/fonc.2022.980694. - DOI - PMC - PubMed

LinkOut - more resources