Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 13;11(6):1097.
doi: 10.3390/vaccines11061097.

Common Adverse Events from Mixing COVID-19 Vaccine Booster in Hanoi, Vietnam

Pham Van Hung  1 , Thai Duy Nguyen  1 , Luu Thi Ha  2 , Phung Lam Toi  3 , Tran Hong Tram  1
Affiliations

Common Adverse Events from Mixing COVID-19 Vaccine Booster in Hanoi, Vietnam

Pham Van Hung et al. Vaccines (Basel). .

Abstract

Background: Mixing vaccines was proposed as a solution to tackle supply chain interruptions during the crisis of the COVID-19 pandemic. This study aimed to investigate the safety of mixing COVID-19 vaccines for a booster dose in Hanoi, Vietnam.

Method: A cross-sectional study was conducted via a telephone-based interview to identify the adverse events following COVID-19 vaccination among 719 participants in Hanoi, Vietnam.

Results: In total, 45.76% of participants experienced at least one adverse event following two doses of the COVID-19 vaccine. Most of the adverse events were local effects with mild symptoms such as fever, headache, muscle pain, and/or pain at the site. In general, matching two doses in the same vaccines was not associated with the adverse events as compared to mixing vaccines (OR = 1.43, 96%CI: 0.93-2.2), except matching two doses of Pfizer (OR = 2.25, 95%CI: 1.33-3.82).

Conclusion: The findings of this study suggest the overall safety of mixed vaccination. In light of the vaccine shortage, mixing vaccinations for COVID-19 prevention is a good solution. Further studies with larger cohorts and investigating immunity following mixing vaccines are needed to elucidate the mechanism.

Keywords: COVID-19; Vietnam; adverse events; matching; mixing; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. McMurry R., Lenehan P., Awasthi S., Silvert E., Puranik A., Pawlowski C., Venkatakrishnan A., Anand P., Agarwal V., O’horo J.C., et al. Real-time analysis of a mass vaccination effort confirms the safety of FDA-authorized mRNA COVID-19 vaccines. Med. 2021;2:965–978.e965. doi: 10.1016/j.medj.2021.06.006. - DOI - PMC - PubMed
    1. Shemer A., Pras E., Einan-Lifshitz A., Dubinsky-Pertzov B., Hecht I. Association of COVID-19 Vaccination and Facial Nerve Palsy: A Case-Control Study. JAMA Otolaryngol. Neck Head Surg. 2021;147:739. doi: 10.1001/jamaoto.2021.1259. - DOI - PMC - PubMed
    1. Polewska K., Tylicki P., Biedunkiewicz B., Rucińska A., Szydłowska A., Kubanek A., Rosenberg I., Rodak S., Ślizień W., Renke M., et al. Safety and Tolerability of the BNT162b2 mRNA COVID-19 Vaccine in Dialyzed Patients. COViNEPH Project. Medicina. 2021;57:732. doi: 10.3390/medicina57070732. - DOI - PMC - PubMed
    1. Goldshtein I., Nevo D., Steinberg D.M., Rotem R.S., Gorfine M., Chodick G., Segal Y. Association between BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women. JAMA. 2021;12:e2111035. doi: 10.1001/jama.2021.11035. - DOI - PMC - PubMed
    1. Atmar R.L., Lyke K.E., Deming M.E., Jackson L.A., Branche A.R., El Sahly H.M., Rostad C.A., Martin J.M., Johnston C., Rupp R.E., et al. Homologous and Heterologous COVID-19 Booster Vaccinations. N. Engl. J. Med. 2022;386:1046–1057. doi: 10.1056/NEJMoa2116414. - DOI - PMC - PubMed

LinkOut - more resources