Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 22:16:4013-4023.
doi: 10.2147/IDR.S416860. eCollection 2023.

The New Changes of Epidemiology, Etiology, and Clinical Characteristics of Pyogenic Liver Abscesses: A Retrospective Study in a Hospital in Northern China

JinHua Cui  1 , YaMan Liu  2 , Jian Li  1
Affiliations

The New Changes of Epidemiology, Etiology, and Clinical Characteristics of Pyogenic Liver Abscesses: A Retrospective Study in a Hospital in Northern China

JinHua Cui et al. Infect Drug Resist. .

Abstract

Purpose: To investigate the epidemiology, etiology, and clinical characteristics of patients with pyogenic liver abscesses (PLA) and provide guidance for clinical treatments.

Patients and methods: A retrospective study was performed on a cohort of 402 hospitalized patients diagnosed with PLAs at the Affiliated Hospital of Chengde Medical College between January 2016 and December 2021. Patient demographics, drug sensitivity profiles, and microbiological culture results of drainage and blood samples were thoroughly analyzed to identify significant patterns or trends. Furthermore, clinical characteristics and treatments for patients with PLA were comprehensively assessed.

Results: Patients aged 50-69 years had the highest incidence of PLA, accounting for 59.9% of all cases, and 91.5% of them had a fever. Bacterial culture analysis of the 200 patients revealed that Klebsiella pneumoniae (K. pneumoniae) was the most predominant pathogen, detected in 70.5% of cases, exhibiting an upward trend. Escherichia coli (E. coli) was the second most frequently detected pathogen, identified in 14.5% of cases, showing a downward trend. Coexisting diabetes mellitus (DM) was found to be the most common comorbidity for PLA, occurring in most patients with the condition. Patients with a history of abdominal surgery and malignancy had an increased risk for PLA, while those with gallstones had a decreased risk. Drainage combined with antibiotic therapy was identified as the primary treatment of PLA. In addition, multivariate analysis demonstrated that coexisting DM and the presence of gas in the abscess cavity were independent risk factors for septic shock in patients with PLA.

Conclusion: This study reveals a shift in the proportions of pathogens and risk factors in patients with PLA, underscoring the necessity for improved diagnostic and therapeutic strategies.

Keywords: Klebsiella pneumoniae; diabetes; morbidity; pathogen; pyogenic liver abscess.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Age distribution of patients with pyogenic liver abscess.
Figure 2
Figure 2
Comorbidities for PLAs.
Figure 3
Figure 3
Common etiological changes in PLAs (K. pneumoniae and Escherichia coli).
Figure 4
Figure 4
Comparison of the antibiotic susceptibility of common bacteria (K. pneumoniae and Escherichia coli).
See this image and copyright information in PMC

References

    1. Jepsen P, Vilstrup H, Schønheyder HC, et al. A nationwide study of the incidence and 30-day mortality rate of pyogenic liver abscess in Denmark, 1977–2002. Aliment Pharmacol Ther. 2005;21(10):1185–1188. doi:10.1111/j.1365-2036.2005.02487.x - DOI - PubMed
    1. Liisa M, Myers Robert P, James H, et al. A population-based study of pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends. Am J Gastroenterol. 2010;105(1):117–124. doi:10.1038/ajg.2009.614 - DOI - PubMed
    1. Losie Jennifer A, Lam John C, Gregson Daniel B, et al. Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study. BMC Infect Dis. 2021;21(1):939. doi:10.1186/s12879-021-06649-9 - DOI - PMC - PubMed
    1. Laupland Kevin B, Church Deirdre L, Melissa M, et al. Population-based study of the epidemiology of and the risk factors for invasive staphylococcus aureus infections. J Infect Dis. 2003;187(9):1452–1459. doi:10.1086/374621 - DOI - PubMed
    1. Cristina S, Chiara E, Christian B, et al. Characteristics and management of pyogenic liver abscess: a European experience. Medicine. 2018;97(19):e0628. doi:10.1097/MD.0000000000010628 - DOI - PMC - PubMed