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. 2023 May;23(2):271-273.
doi: 10.18295/squmj.12.2022.064. Epub 2023 May 31.

Giant Mediastinal Myxoid Pleomorphic Liposarcoma

Adil H Al Kindi  1 , Faiza A Al Kindi  2 , Marwa Al Riyami  3 , Essam Khalil  1
Affiliations

Giant Mediastinal Myxoid Pleomorphic Liposarcoma

Adil H Al Kindi et al. Sultan Qaboos Univ Med J. 2023 May.
No abstract available

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Figures

Figure 1
Figure 1
A: Anteroposterior chest x-ray of an 18-year-old female patient showing an abnormal contouring of the mediastinum with a large lesion in the anterior mediastinum and the left lower hemithorax. Hilar overlay sign is noted with both hilar shadows identified through the opacity of the abnormal lesion. B & C: Chest computed tomography images with IV contrast in the (B) axial and (C) coronal views showing a large heterogeneous mass occupying the anterior mediastinum, right and left hemithorax with posterior displacement of the heart and atelectasis of the lungs. The mass shows areas of low density (arrow) likely representing fat content and other areas of high density (arrowhead) representing calcification.
Figure 2
Figure 2
A: Intraoperative photographs showing clam-shell incision exposing the anterior mediastinum and bilateral pleura. B: Photograph of the excised mass which was yellow, encapsulated and lobulated measuring 22 × 18 × 13 cm in size.
Figure 3
Figure 3
A: Low power examination showed an encapsulated multinodular malignant neoplasm of variable cellularity (hematoxylin and eosin stain, magnification ×40). B: lipomatous areas showing atypical multivacuolated lipoblasts (arrows) (hematoxylin and eosin stain, magnification ×100). C: other areas showed myxoid stroma containing plump spindle to stellate cells (hematoxylin and eosin stain, magnification ×100). D: highly cellular nodules formed of fascicles of pleomorphic spindle cells with frequent mitotic figures (arrow) (hematoxylin and eosin stain, magnification ×200).
Figure 4
Figure 4
A: Areas of geographic coagulative type necrosis seen (arrow) (hematoxylin and eosin stain, magnification ×100). B: S-100 immunostain showed positive staining of tumor cells in the lipomatous areas (magnification ×100). C: s-100 immunostain was negative in the cellular pleomorphic areas (magnification ×100). D: Tumor cells were negative for cyclin dependent kinase 4 (CDK4) (magnification ×400).
See this image and copyright information in PMC

References

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