The prospects and challenges of chimeric antigen receptor T cell therapy for head and neck squamous cell carcinoma

Wei Liu^{1

2

3}, Xuemin Shen^{1

3}, Zhenhu Ren^{2

3

4}, Xi Yang^{2

3

4}

Affiliations

¹ Department of Oral Mucosal Diseases.
² Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
³ College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
⁴ Department of Oral and Maxillofacial Surgery, Zhang Zhiyuan Academician Workstation, Hainan Western Central Hospital, Shanghai Ninth People's Hospital, Danzhou, Hainan, China.

PMID: 37379201
PMCID: PMC10498852
DOI: 10.1097/JS9.0000000000000527

Comment

The prospects and challenges of chimeric antigen receptor T cell therapy for head and neck squamous cell carcinoma

Wei Liu et al. Int J Surg. 2023.

. 2023 Sep 1;109(9):2868-2871.

doi: 10.1097/JS9.0000000000000527.

Authors

Wei Liu^{1

2

3}, Xuemin Shen^{1

3}, Zhenhu Ren^{2

3

4}, Xi Yang^{2

3

4}

Affiliations

¹ Department of Oral Mucosal Diseases.
² Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.
³ College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
⁴ Department of Oral and Maxillofacial Surgery, Zhang Zhiyuan Academician Workstation, Hainan Western Central Hospital, Shanghai Ninth People's Hospital, Danzhou, Hainan, China.

PMID: 37379201
PMCID: PMC10498852
DOI: 10.1097/JS9.0000000000000527

No abstract available

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Comment on

Therapeutic implication of chimeric antigen receptor T-cell therapy for head and neck squamous cell carcinoma.
Pazhani J, Jayaraman S, Veeraraghavan VP. Pazhani J, et al. Int J Surg. 2023 Mar 1;109(3):230-231. doi: 10.1097/JS9.0000000000000018. Int J Surg. 2023. PMID: 37093067 Free PMC article. No abstract available.

References

1. Sankar S. New insights into CAR T-cell therapy for recurrent head and neck squamous cell carcinoma. Oral Oncol 2022;134:106137. - PubMed
1. Pazhani J, Jayaraman S, Veeraraghavan VP. Therapeutic implication of chimeric antigen receptor T-cell therapy for head and neck squamous cell carcinoma. Int J Surg 2023;109:230–231. - PMC - PubMed
1. Lin YC, Hua CH, Lu HM, et al. CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer. iScience 2023;26:106089. - PMC - PubMed
1. Haist C, Poschinski Z, Bister A, et al. Engineering a single-chain variable fragment of cetuximab for CAR T-cell therapy against head and neck squamous cell carcinomas. Oral Oncol 2022;129:105867. - PubMed
1. Haist C, Schulte E, Bartels N, et al. CD44v6-targeted CAR T-cells specifically eliminate CD44 isoform 6 expressing head/neck squamous cell carcinoma cells. Oral Oncol 2021;116:105259. - PubMed

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The prospects and challenges of chimeric antigen receptor T cell therapy for head and neck squamous cell carcinoma

Affiliations

The prospects and challenges of chimeric antigen receptor T cell therapy for head and neck squamous cell carcinoma

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Substances

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Full Text Sources

Medical