The structure of megalin: shedding new light on receptor-mediated endocytosis

Affiliations

¹ Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
² Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Institute for Rare Diseases, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium. Electronic address: olivier.devuyst@uzh.ch.

Comment

Svenja Keller et al. Kidney Int. 2024 Jan.

. 2024 Jan;105(1):11-14.

doi: 10.1016/j.kint.2023.05.026. Epub 2023 Jun 26.

¹ Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
² Institute of Physiology, Zurich Centre for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Institute for Rare Diseases, Cliniques universitaires Saint-Luc, UCLouvain, Brussels, Belgium. Electronic address: olivier.devuyst@uzh.ch.

No abstract available

Keywords: Donnai-Barrow syndrome; Heymann nephritis; LRP2; cryoelectron microscopy; proximal tubule; renal Fanconi syndrome.

Comment on

Structures of LRP2 reveal a molecular machine for endocytosis.
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L. Beenken A, et al. Cell. 2023 Feb 16;186(4):821-836.e13. doi: 10.1016/j.cell.2023.01.016. Epub 2023 Feb 6. Cell. 2023. PMID: 36750096 Free PMC article.