Decoding a ribosome uncertainty
- PMID: 37380507
- DOI: 10.1016/j.tig.2023.06.001
Decoding a ribosome uncertainty
Abstract
The ribosome is among the most ancient macromolecular complexes. Throughout evolution, the function of the ribosome has remained essential and conserved: the decoding of an mRNA template with tRNA-linked amino acids, to synthesize a protein. In a recent study, Holm et al. capture evolutionary distinctions in the structure and kinetics of 'mRNA decoding' by the human ribosome.
Copyright © 2023 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests No interests are declared.
Comment on
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mRNA decoding in human is kinetically and structurally distinct from bacteria.Nature. 2023 May;617(7959):200-207. doi: 10.1038/s41586-023-05908-w. Epub 2023 Apr 5. Nature. 2023. PMID: 37020024 Free PMC article.
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