Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 28;18(1):42.
doi: 10.1186/s13024-023-00637-0.

Anti-amyloid therapies for Alzheimer disease: finally, good news for patients

Vijay K Ramanan  1 , Gregory S Day  2
Affiliations

Anti-amyloid therapies for Alzheimer disease: finally, good news for patients

Vijay K Ramanan et al. Mol Neurodegener. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Ramanan receives research funding from the NIH and the Mangurian Foundation for Lewy Body disease research, has provided educational content for Medscape, is PI for a clinical trial sponsored by the Alzheimer’s Association, and is a site clinician for clinical trials sponsored by Eisai, the Alzheimer's Treatment and Research Institute at USC, and Transposon Therapeutics, Inc.

Dr. Day is supported by the NIH (K23AG064029, U01AG057195, U19AG032438), the Alzheimer’s Association, and Chan Zuckerberg Initiative; he serves as a consultant for Parabon Nanolabs Inc, as a Topic Editor (Dementia) for DynaMed (EBSCO), and as the Clinical Director of the Anti-NMDA Receptor Encephalitis Foundation (Inc, Canada; uncompensated); he is the co-Project PI for a clinical trial in anti-NMDAR encephalitis, which receives support from Horizon Pharmaceuticals; he has developed educational materials for PeerView Media, Inc, and Continuing Education Inc; he owns stock in ANI pharmaceuticals; and his institution has received support from Eli Lilly for his development and participation in an educational event promoting early diagnosis of symptomatic Alzheimer disease.

Figures

Fig. 1
Fig. 1
The relative safety and efficacy of putative amyloid-β-lowering therapies in patients with sporadic early-symptomatic Alzheimer disease. The efficacy and safety of selected amyloid-lowering therapies are depicted via scatter plot, referencing available data from Phase 3 clinical trials completed after 2016. Monoclonal antibodies accessible in the US under accelerated approval are depicted in red (donanemab remains under consideration). Other monoclonal antibodies are depicted in black. Agents with other mechanisms of action are depicted in gray. Dashed lines depict clinical meaningfulness. Agents in the top right quadrant met established endpoints for efficacy and safety. For more information consult clinicaltrials.gov, donanemab NCT04437511 [2] lecanemab NCT003887455 [1]; aducanumab NCT02477800, NCT02484547 [5]; gantenerumab NCT02051608, NCT01224106; solanezumab NCT01900665; crenezumab NCT03114657, NCT02670083; elenbecestat NCT012956486; lanabecestat NCT02972658, NCT02245737, NCT02783573; verubecestat NCT01953601
See this image and copyright information in PMC

References

    1. van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in Early Alzheimer's Disease. New England J Med. 2022. N Engl J Med . 2023;388(1):9–21. 10.1056/NEJMoa2212948. - PubMed
    1. Company ELa. Lilly's Donanemab significantly slowed cognitive and functional decline in phase 3 study of early alzheimer’s disease. 2023. Available from: https://investor.lilly.com/news-releases/news-release-details/lillys-don.... Accessed 20 May 2023.
    1. Panza F, Lozupone M, Logroscino G, Imbimbo BP. A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease. Nat Rev Neurol. 2019;15(2):73–88. doi: 10.1038/s41582-018-0116-6. - DOI - PubMed
    1. McDade E, Cummings JL, Dhadda S, Swanson CJ, Reyderman L, Kanekiyo M, et al. Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. Alzheimer’s Res Therapy. 2022;14(1):191. doi: 10.1186/s13195-022-01124-2. - DOI - PMC - PubMed
    1. Day GS, Scarmeas N, Dubinsky R, Coerver K, Mostacero A, West B, et al. Aducanumab Use in Symptomatic Alzheimer Disease Evidence in Focus: A Report of the AAN Guidelines Subcommittee. Neurology. 2022;98(15):619–631. doi: 10.1212/WNL.0000000000200176. - DOI - PMC - PubMed

Substances