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Case Reports
. 2024 Jan-Feb;41(1):91-93.
doi: 10.1111/pde.15379. Epub 2023 Jun 29.

Congenital bullous syphilis in a newborn: A novel approach to diagnosis using immunohistochemical staining on a blister roof

Odera Ekeh  1 , Robert F Duffy  2 , Anat Feingold  3   4 , Steven M Manders  2
Affiliations
Case Reports

Congenital bullous syphilis in a newborn: A novel approach to diagnosis using immunohistochemical staining on a blister roof

Odera Ekeh et al. Pediatr Dermatol. 2024 Jan-Feb.

Abstract

We describe a rare presentation of congenital bullous syphilis in a premature neonate born with extensive skin desquamation. The newborn was noted to have diffuse erythema with widespread, superficial skin desquamation in addition to plantar bullae and erosions, and an absence of mucosal involvement. Immunohistochemical syphilis diagnostic staining was performed on a blister roof, highlighting a novel diagnostic approach for congenital bullous syphilis.

Keywords: congenital bullous syphilis; congenital infection; infectious disease; pemphigus syphiliticus.

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References

REFERENCES

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