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. 2023 Oct;39(7):e3681.
doi: 10.1002/dmrr.3681. Epub 2023 Jun 29.

Lower skeletal muscle mass is associated with diabetes and insulin resistance: A cross-sectional study

Jin Hun Park  1 , Mi-Yeon Lee  2 , Hun-Kyu Shin  1 , Kyung Jae Yoon  3 , JunYeop Lee  1 , Jai Hyung Park  1
Affiliations

Lower skeletal muscle mass is associated with diabetes and insulin resistance: A cross-sectional study

Jin Hun Park et al. Diabetes Metab Res Rev. 2023 Oct.

Abstract

Aims: The association between skeletal muscle mass and diabetes incidence/insulin resistance/glycated hemoglobin (HbA1C) is unknown. The aim of this study was to investigate such association in clinically apparently healthy males and females.

Methods: A cross-sectional study of 372,399 Korean males and females who completed bioelectrical impedance analysis (BIA) in a health-screening programme was performed. Skeletal muscle index was used as an indicator of skeletal muscle mass. Skeletal muscle index (%) [appendicular skeletal muscle mass (kg)/body weight (kg)X100] was estimated using BIA. The study outcomes were diabetes incidence, homoeostasis model assessment of insulin resistance (HOMA-IR), and HbA1C.

Results: The mean age of study participants was 38.92 ± 8.54 years. Multiple logistic regression analysis revealed a significant negative association between Skeletal muscle index and diabetes incidence/HOMA-IR/HbA1C after adjusting for various confounding factors. Odds ratios (95% confidence interval (CI)) of diabetes incidence in Q2, Q3, and Q4 compared to the lowest quantile (Q1) were 0.95 (0.85-1.05), 0.88 (0.78-0.99), and 0.79 (0.69-0.9), respectively. Beta coefficients (95% CI) of HOMA-IR in Q2, Q3, and Q3 with Q1 were 0.05 (0.03-0.07), -0.06 (-0.09∼-0.04), and -0.19 (-0.22∼-0.16), respectively. Beta coefficients (95% CI) of HbA1C in Q2, Q3, and Q4 with Q1 were 0.02 (0.01-0.03), -0.001 (-0.01∼0.01), and -0.02 (-0.03∼-0.01), respectively.

Conclusions: This study demonstrated negative associations of skeletal muscle mass with diabetes incidence, insulin resistance, and HbA1C levels in healthy adults.

Keywords: HbA1C; diabetes; insulin resistance; sarcopenia; skeletal muscle mass.

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References

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