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Review
. 2023 Sep 1;38(5):456-461.
doi: 10.1097/HCO.0000000000001065. Epub 2023 May 18.

Sleep apnea and cardiovascular risk

Manu Rajachandran  1 , Nils Nickel, Richard A Lange
Affiliations
Review

Sleep apnea and cardiovascular risk

Manu Rajachandran et al. Curr Opin Cardiol. .

Abstract

Purpose of review: Obstructive sleep apnea (OSA) is associated with several cardiovascular risk predictors that have only recently begun to be studied in detail. The strong association between OSA and hypertension, coronary artery disease, congestive heart failure, and sudden cardiac death underscores its significant impact on cardiovascular health. This brief review considers the links between OSA and cardiovascular risk.

Recent findings: OSA is an important contributor to endothelial dysfunction and damage, while repetitive hypoxia and hypercarbia contribute to autonomic dysfunction and sympathetic stimulation. In turn, these derangements have deleterious hematologic effects, including hypercoagulability and abnormal platelet aggregability, which are important in the pathogenesis of atherothrombotic disease.

Summary: The varied deleterious effects of OSA on cardiovascular health stem from a unique 'perfect storm' of hypoxic oxidative stress, autonomic dysregulation, endothelial damage, and inflammation occurring at the microvascular level. Further research may disentangle these multiple etiologic threads and provide a better understanding of the underlying pathophysiological relationship between OSA and cardiovascular disease.

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References

    1. Monahan K, Redline S. Role of obstructive sleep apnea in cardiovascular disease. Curr Opin Cardiol 2011; 26:541.
    1. De Olazabal JR, Miller MJ, Cook WR, Mithoefer JC. Disordered breathing and hypoxia during sleep in coronary artery disease. Chest 1982; 82:548–552.
    1. Lüthje L, Andreas S. Obstructive sleep apnea and coronary artery disease. Sleep Med Rev 2008; 12:19–31.
    1. Koehler U, Schäfer H. Is obstructive sleep apnea (OSA) a risk factor for myocardial infarction and cardiac arrhythmias in patients with coronary heart disease (CHD)? Sleep 1996; 19:283–286.
    1. Kapen S, Park A, Goldberg J, Whynter J. The incidence and severity of obstructive sleep apnea in ischemic cerebrovascular disease. Neurology 1991; 41: (Suppl. 1): 125.