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Practice Guideline
. 2024 Apr 1;122(2):e202202948.
doi: 10.5546/aap.2022-02948.eng. Epub 2023 Jul 6.

Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis in pediatrics

[Article in English, Spanish]
Oscar Brunetto  1 , Hamilton R Cassinelli  2 , Graciela Espada  3 , Gisela L Viterbo  4 , Silvia M Meiorin  5 , María F Ahumada  6 , Luciana Brenzoni  7 , María C Maher  8 , Ignacio Chavero  9 , Luis A Ramírez Stieben  10 , María L Brance  11
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Free article
Practice Guideline

Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis in pediatrics

[Article in English, Spanish]
Oscar Brunetto et al. Arch Argent Pediatr. .
Free article

Abstract
in English, Spanish

Objective. To provide a framework for healthcare professionals managing pediatric patients who are on active glucocorticoid (GC) therapy and to develop recommendations for the prevention and treatment of GC-induced osteoporosis in the pediatric population. Methods. A panel of experts on bone and pediatric diseases developed a series of PICO questions that address issues related to the prevention and treatment of osteoporosis in patients on GC therapy. In accordance with the GRADE approach, we conducted a systematic review of the literature, summarized effect estimations, and classified the quality of the evidence. Then, voting and the formulation of recommendations followed. Results. Seven recommendations and six general principles were developed for GC-induced osteoporosis in the pediatric population. Conclusion. These recommendations provide guidance for clinicians who must make decisions concerning pediatric patients undergoing treatment with GC.

Objetivo. Proporcionar un marco para profesionales de la salud que tratan a pacientes pediátricos bajo terapia con glucocorticoides (GC) y desarrollar recomendaciones para la prevención y el tratamiento de la osteoporosis inducida por GC en la población pediátrica. Métodos. Un panel de expertos en enfermedades óseas y pediátricas generó una serie de preguntas PICO que abordan aspectos relacionados con la prevención y el tratamiento de osteoporosis en pacientes bajo tratamiento con GC. Siguiendo la metodología GRADE, se realizó una revisión sistemática de la literatura, se resumieron las estimaciones del efecto y se calificó la calidad de la evidencia. Luego se procedió a la votación y a la formulación de las recomendaciones. Resultados. Se desarrollaron 7 recomendaciones y 6 principios generales para osteoporosis inducida por GC en población pediátrica. Conclusión. Estas recomendaciones proporcionan orientación para los médicos que deben tomar decisiones en pacientes pediátricos bajo tratamiento con GC.

Keywords: clinical practice guidelines; glucocorticoids; osteoporosis; pediatrics.

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