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. 2023 Jun 16;9(6):e17215.
doi: 10.1016/j.heliyon.2023.e17215. eCollection 2023 Jun.

Systematic review and meta-analysis of tuberculosis in animals in Nigeria

Ibrahim Ahmad  1   2 , Yakubu Egigogo Raji  3 , Latiffah Hassan  2 , Abdullahi Samaila  4 , Basiru Aliyu  5 , Jakob Zinsstag  6 , Folorunso O Fasina  7   8
Affiliations

Systematic review and meta-analysis of tuberculosis in animals in Nigeria

Ibrahim Ahmad et al. Heliyon. .

Abstract

Animal tuberculosis (TB) is a contagious and chronic disease caused by mycobacteria belonging to theMycobacterium tuberculosis complex (MTBC) in domestic and wild animals. MTBC strains infection has been confirmed in many animal species in Nigeria, including captive wildlife, cattle, dromedary camels, goats, and pigs. Despite widespread infection and the potential impact of the disease on public health, active surveillance and control strategies are absent in Nigeria. This study aimed to conduct the first comprehensive meta-analysis to assess the distribution of tuberculosis and analyze the potential moderators of infection in animals in Nigeria. Eligible studies (sixty-one (Cadmus et al., 2014) [61] prevalence and seven (Menzies and Neill, 2000) [7] case reports) were retrieved and included in the analysis. The analyses showed an overall pooled TB prevalence of 7.0% (95% CI: 6.0-8.0) comprising of infection distributed in cattle (8.0%, 95% CI: 7.0-8.0), goats (0.47%, 95% CI: 0-1.2), sheep (0.27%, 95% CI: 0.14-0.46), camels (13.0%, 95% CI: 0-47), and wildlife (13.0%, 95% CI: 9-16) respectively. The occurrence of infection was significantly moderated by the publication periods, geographical location, sample size, and detection methods. TB prevalence was heterogeneous across several predictors, with the year of publication exhibiting a higher rate (46%) of the detected heterogeneity. These findings should provide policy-relevant information to guide the design and establishment of prevention and control measures amenable to the local situations in Nigeria.

Keywords: Animal tuberculosis; Epidemiology; Livestock; Nigeria; Wildlife; meta-Analysis.

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Conflict of interest statement

None of the authors has any interest that should prevent the publication of this manuscript.

Figures

Fig. 1
Fig. 1
PRISMA flowchart.
Fig. 2
Fig. 2
Forest plot of meta-analysis of animal TB (overall) prevalence in Nigeria.
Fig. 3
Fig. 3
Forest plot of overall subgroup analysis (involving cattle, goat, sheep, camel, and wildlife).
Fig. 4
Fig. 4
Funnel plot of double arcsine prevalence against standard error showing observed asymmetry.
Fig. 5
Fig. 5
Doi plot of double arcsine prevalence against Z-score showing evidence of major asymmetry.
See this image and copyright information in PMC

References

    1. Gortázar C., Fernández-Calle L.M., Collazos-Martínez J.A., Mínguez-González O., Acevedo P. Animal tuberculosis maintenance at low abundance of suitable wildlife reservoir hosts: a case study in northern Spain. Prev. Vet. Med. 2017;146:150–157. doi: 10.1016/j.prevetmed.2017.08.009. - DOI - PubMed
    1. Stański K., Lycett S., Porphyre T., Bronsvoort B.M., de C. Using machine learning improves predictions of herd-level bovine tuberculosis breakdowns in Great Britain. Sci. Rep. 2021;11(2208) doi: 10.1038/s41598-021-81716-4. - DOI - PMC - PubMed
    1. Gormley E., Corner L.A.L. Wild animal tuberculosis: stakeholder value systems and management of disease. Front Vet Sci.. 5. 2018 doi: 10.3389/fvets.2018.00327. - DOI - PMC - PubMed
    1. Inlamea O.F., Soares P., Ikuta C.Y., Heinemann M.B., Achá S.J., Machado A., Ferreira Neto J.S., Correia-Neves M., Rito T. Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests co-evolution with livestock and humans. PLoS Negl Trop Dis. 14, e0008081. 2020. - DOI - PMC - PubMed
    1. Dejene S.W., Heitkönig I.M.A., Prins H.H.T., Lemma F.A., Mekonnen D.A., Alemu Z.E., Kelkay T.Z., de Boer W.F. Risk Factors for Bovine Tuberculosis (bTB) in Cattle in Ethiopia. PLoS One. 11, e0159083. 2016. - DOI - PMC - PubMed

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