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Review
. 2023 May 26;11(15):3408-3417.
doi: 10.12998/wjcc.v11.i15.3408.

Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms

Milko Bozhidarov Mirchev  1 , Irina Boeva  1 , Monika Peshevska-Sekulovska  2 , Veselin Stoitsov  1 , Milena Peruhova  3
Affiliations
Review

Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms

Milko Bozhidarov Mirchev et al. World J Clin Cases. .

Abstract

High rates of extrapancreatic malignancies, in particular colorectal cancer (CRC), have been detected in patients with intraductal papillary mucinous neoplasm (IPMN). So far, there is no distinct explanation in the literature for the development of secondary or synchronous malignancies in patients with IPMN. In the past few years, some data related to common genetic alterations in IPMN and other affiliated cancers have been published. This review elucidated the association between IPMN and CRC, shedding light on the most relevant genetic alterations that may explain the possible relationship between these entities. In keeping with our findings, we suggested that once the diagnosis of IPMN is made, special consideration of CRC should be undertaken. Presently, there are no specific guidelines regarding colorectal screening programs for patients with IPMN. We recommend that patients with IPMNs are at high-risk for CRC, and a more rigorous colorectal surveillance program should be implemented.

Keywords: Colorectal cancer; Extrapancreatic malignancies; Genetic alterations; Intraductal papillary mucinous neoplasm; Synchronous neoplasms.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Gene mutations in different intraductal papillary mucinous neoplasm tumorigenesis pathways. IPMN: Intraductal papillary mucinous neoplasm.
Figure 2
Figure 2
Mutations in carcinogenesis of intraductal papillary mucinous neoplasm and colorectal cancer. A: The proposed model of progression pathways during carcinogenesis of intraductal papillary mucinous neoplasm (IPMN). The light circles, triangles, pentagons, and rectangles denote the diversity of precursors; B: The precursors include pancreatic intraepithelial neoplasia and incipient IPMN, with a distinct set of driver mutations (KRAS and GNAS). CRC: Colorectal cancer; PDA: Pancreatic ductal adenocarcinoma.
See this image and copyright information in PMC

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