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. 2023 Apr 28;48(4):594-600.
doi: 10.11817/j.issn.1672-7347.2023.220608.

Research progress on animal models of contrast-induced acute kidney injury

[Article in English, Chinese]
Ke Deng  1 , Mingxin Pei  2 , Yanling Chen  3
Affiliations

Research progress on animal models of contrast-induced acute kidney injury

[Article in English, Chinese]
Ke Deng et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Contrast-induced acute kidney injury (CI-AKI) refers to acute kidney injury that occurs after intravascular contrast media is applied. It is the third most common cause for acute renal failure in hospitalized patients and can cause severe renal impairment and adverse cardiovascular outcomes. In severe cases, it can even lead to the death of the patient. Due to its complicated pathogenesis, the pathogenesis of CI-AKI has not yet been elucidated. Therefore, it is of great significance to further study the pathogenesis for the prevention of CI-AKI. Moreover, a good animal model of CI-AKI is an important tool for in-depth research on the pathogenesis of acute kidney injury induced by contrast agents.

造影剂诱导的急性肾损伤(contrast-induced acute kidney injury，CI-AKI)是指血管内应用造影剂后出现的急性肾损伤，是住院患者发生急性肾衰竭的第三大常见原因，可造成严重肾功能损害和不良心血管结局，严重情况下还可导致患者死亡。CI-AKI的发病机制复杂，目前尚未阐明，研究CI-AKI的发病机制对其防治具有重要意义，良好的CI-AKI动物模型是深入研究CI-AKI发病机制的重要基础。.

Keywords: animal models; contrast-induced acute kidney injury; renal impairment.

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Conflict of interest statement

作者声称无任何利益冲突。

Figures

图1
图1
CI-AKI动物模型文献研究关键热词 Figure 1 Key hot words in literature research on CI-AKI animal model L-NAME：N-nitro-L arginine methyl ester.
See this image and copyright information in PMC

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