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. 2023 May 26:20:63.
eCollection 2023.

Comparison of oral candidiasis characteristics in head-and-neck cancer patients before and during radiotherapy

Zahra Golestannejad  1 , Faezeh Khozeimeh  1 , Nadia Najafizade  2 , Adel Tabesh  1 , Elham Faghihian  1 , Mehrnoush Maheronnaghsh  3 , Mahnaz Kheirkhah  3 , Sayed Mohsen Hosseini  4 , Leila Sadeghalbanaei  5 , Mina Jamshidi  6 , Ahmad Amiri Chermahini  7 , Zahra Saberi  1 , Fahimeh Pakravan  8 , Parvin Dehghan  9 , Maryam Emamibafrani  10 , Nima Amini  11 , Faezeh Tadayon  10
Affiliations

Comparison of oral candidiasis characteristics in head-and-neck cancer patients before and during radiotherapy

Zahra Golestannejad et al. Dent Res J (Isfahan). .

Abstract

Background: Patients undergoing head-and-neck radiotherapy are susceptible to Candida colonization and infection. This study aimed to identify oral Candida species type (ST), colony count (CC), and oropharyngeal candidiasis (OPC) in head-and-neck cancer patients, undergoing radiotherapy, before and 2 weeks after radiation.

Materials and methods: In this quasi-experimental study, head-and-neck cancer patients undergoing radiotherapy (up to 6000 cGy) were recruited. Samples were taken before and 2 weeks after radiation therapy (RT). CC was assigned using Sabouraud dextrose agar culture medium and morphological studies were performed to confirm OPC. For identification, polymerase chain reaction-restriction fragment length polymorphism was performed. Data were analyzed using Chi-square-test and kappa coefficient. P < 0.05 was considered statistically significant.

Results: Twenty-one of 33 patients were Candida positive. The detected fungal species included Candida albicans (60%), Candida tropicalis (22%), Candida glabrata (9%), and other species (9%). Following RT, OPC and CC changed significantly (P = 0.003 and P = 0.001, respectively), whereas ST did not significantly change (P = 0.081). Two new species (Candida krusei and Candida parapsilosis) were detected after the intervention. The OPC, CC, and ST changes after RT were not significantly related to malignancy site or radiation dose (P > 0.05).

Conclusion: The present study showed that OPC, CC, and ST were not related to the malignancy site. Following RT, OPC and CC changed significantly, while ST showed no significant change. The radiation dose and malignancy site had no effects on the OPC, CC, or ST alterations following RT.

Keywords: Candida; head-and-neck neoplasms; radiotherapy.

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Conflict of interest statement

The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or non-financial in this article.

Figures

Figure 1
Figure 1
The frequency of species in Candida-positive patients before and 2 weeks after radiation therapy.
See this image and copyright information in PMC

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