Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul;23(7):256-263.
doi: 10.1016/j.bjae.2023.03.008. Epub 2023 Jun 7.

Anticoagulation for cardiopulmonary bypass, Part 2: alternatives and pathological states

Affiliations
Review

Anticoagulation for cardiopulmonary bypass, Part 2: alternatives and pathological states

B Cartwright et al. BJA Educ. 2023 Jul.
No abstract available

Keywords: anticoagulation; cardiopulmonary bypass; cardiothoracic anaesthesia.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig 1
Fig 1
Cycle of HIT. The activation of platelets by heparin sets up a feedback loop by formation of immune complexes capable of causing platelet degranulation.
Fig 2
Fig 2
The interaction of bivalirudin and argatroban with thrombin (Factor II) is distinct to heparin.

References

    1. Cartwright B., Mundell N. Anticoagulation for cardiopulmonary bypass: part one. BJA Educ. 2023;23:110–116. - PMC - PubMed
    1. Marchetti M., Zermatten M.G., Calderara D.B., Aliotta A., Alberio L. Heparin-induced thrombocytopenia: a review of new concepts in pathogenesis, diagnosis, and management. J Clin Med. 2021;10:683. - PMC - PubMed
    1. Crow J.R., Nam L., Chasler J.E., et al. Association of heparin dose, route, timing, and duration with heparin-induced thrombocytopenia. Ann Thorac Surg. 2021;112:32–37. - PubMed
    1. Greinacher A., Farner B., Kroll H., Kohlmann T., Warkentin T.E., Eichler P. Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. Thromb Haemost. 2005;94:132–135. - PubMed
    1. Amiral J., Vissac A.M. Generation and pathogenicity of anti-platelet factor 4 antibodies: diagnostic implications. Clin Appl Thromb Hemost. 1999;5:S28–S31. - PubMed