Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun;46(6):449-499.
doi: 10.1007/s12272-023-01453-2. Epub 2023 Jun 30.

Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure-activity relationship, and biosynthesis

Peng Jiang #  1   2 , Xiujuan Fu #  3 , Hong Niu  3 , Siwei Chen  3 , Feifei Liu  4 , Yu Luo  3 , Dan Zhang  5 , Hui Lei  6
Affiliations
Review

Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure-activity relationship, and biosynthesis

Peng Jiang et al. Arch Pharm Res. 2023 Jun.

Abstract

Strains of the fungal genus Pestalotiopsis are reported as large promising sources of structurally varied biologically active metabolites. Many bioactive secondary metabolites with diverse structural features have been derived from Pestalotiopsis. Moreover, some of these compounds can potentially be developed into lead compounds. Herein, we have systematically reviewed the chemical constituents and bioactivities of the fungal genus Pestalotiopsis, covering a period ranging from January 2016 to December 2022. As many as 307 compounds, including terpenoids, coumarins, lactones, polyketides, and alkaloids, were isolated during this period. Furthermore, for the benefit of readers, the biosynthesis and potential medicinal value of these new compounds are also discussed in this review. Finally, the perspectives and directions for future research and the potential applications of the new compounds are summarized in various tables.

Keywords: Bioactivity; Biosynthesis; Chemical constituents; Pestalotiopsis.

PubMed Disclaimer

References

    1. Akhberdi O, Zhang Q, Wang HC, Li YY, Chen LF, Wang D, Yu X, Wei DS, Zhu X (2018) Roles of phospholipid methyltransferases in pycnidia development, stress tolerance and secondary metabolism in the taxol-producing fungus Pestalotiopsis microspore. Microbiol Res 210:33–42. https://doi.org/10.1016/j.micres.2018.03.001 - DOI - PubMed
    1. Anderson JR, Briant CE, Edwards RL, Mabelis RP, Poyser JP, Spencer H, Whalley AJS (1984) Punctatin A (antibiotic M95464): X-ray crystal structure of a sesquiterpene alcohol with a new carbon skeleton from the fungus, Paronia punctata. J Chem Soc, Chem Commun. https://doi.org/10.1039/c39840000405 - DOI
    1. Beattie KD, Ellwood N, Kumar R, Yang XZ, Healy PC, Choomuenwai V, Quinn RJ, Elliott AG, Huang JX, Chitty JL, Fraser JA, Cooper MA, Davis RA (2016) Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F. Phytochemistry 124:79–85. https://doi.org/10.1016/j.phytochem.2015.12.014 - DOI - PubMed
    1. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O’Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141–147. https://doi.org/10.1038/417141a - DOI - PubMed
    1. Bertrand S, Bohni N, Schnee S, Schumpp O, Gindro K, Wolfender JL (2014) Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery. Biotechnol Adv 32:1180–1204. https://doi.org/10.1016/j.biotechadv.2014.03.001 - DOI - PubMed

LinkOut - more resources