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Clinical Trial
. 1979;57(2):275-9.

Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine

E B Doberstyn, P Phintuyothin, S Noeypatimanondh, C Teerakiartkamjorn
Clinical Trial

Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine

E B Doberstyn et al. Bull World Health Organ. 1979.

Abstract

A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.

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References

    1. Antimicrob Agents Chemother. 1973 Feb;3(2):224-7 - PubMed
    1. Southeast Asian J Trop Med Public Health. 1972 Jun;3(2):190-7 - PubMed
    1. Science. 1975 Nov 21;190(4216):792-4 - PubMed

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