Mitochondrial control of sleep

Abstract

The function of sleep remains one of biology's biggest mysteries. A solution to this problem is likely to come from a better understanding of sleep homeostasis, and in particular of the cellular and molecular processes that sense sleep need and settle sleep debt. Here, we highlight recent work in the fruit fly showing that changes in the mitochondrial redox state of sleep-promoting neurons lie at the heart of a homeostatic sleep-regulatory mechanism. Since the function of homeostatically controlled behaviours is often linked to the regulated variable itself, these findings corroborate with the hypothesis that sleep serves a metabolic function.

Keywords: Drosophila; Excitability; Metabolism; Mitochondria; OXPHOS; Oxidative phosphorylation; ROS; Reactive oxygen species; Redox state; Sleep; Sleep homeostasis; Sleep need.