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Case Reports
. 2023 Dec;62(12):1281-1286.
doi: 10.1016/j.jaac.2023.05.028. Epub 2023 Jun 28.

Manifestation of Catatonia in an Adolescent With 22q11.2 Syndrome

Katherine Termini  1 , Ekta Anand  2 , Tucker Hickox  3 , Lucas D Richter  1 , Joshua Ryan Smith  4
Affiliations
Case Reports

Manifestation of Catatonia in an Adolescent With 22q11.2 Syndrome

Katherine Termini et al. J Am Acad Child Adolesc Psychiatry. 2023 Dec.

Abstract

In this Letter to the Editor, we present a case of 22q11.2 deletion syndrome that was diagnosed in an adolescent girl after the onset of acute catatonic symptoms. We discuss the challenges in diagnosing catatonia in children and patients with comorbid neurodevelopmental disorders (NDDs), especially in the setting of recent traumatic exposure. We then review treatment strategies in this patient population and conclude with our recommendations regarding genetic workup in acute catatonia. The patient and guardians have reviewed this article and provided informed consent for its publication. In addition, the authors used the CARE guidelines and checklist in writing this report (Supplement 1, available online).

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Conflict of interest statement

Disclosure: Dr. Smith has received salary support and research funding for other projects from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (1P50HD103537). He is the principal investigator in a clinical trial sponsored by Axial Therapeutics. He is also a sub-investigator in clinical trials sponsored by Janssen Pharmaceuticals and Roche. He receives no salary support from these industry-sponsored clinical trials. Dr. Termini, Ms. Anand, and Messrs. Hickox and Richter have no reported biomedical financial interests or potential conflicts of interest.

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