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Meta-Analysis
. 2023;13(5):681-698.
doi: 10.3233/JPD-230057.

Respiratory-Swallow Coordination in Individuals with Parkinson's Disease: A Systematic Review and Meta-Analysis

Rabab Rangwala  1 , Raneh Saadi  1 , Jungwha Julia Lee  2 , Erin L Reedy  1   3 , Cagla Kantarcigil  1 , Megan Roberts  1 , Bonnie Martin-Harris  1   4   3
Affiliations
Meta-Analysis

Respiratory-Swallow Coordination in Individuals with Parkinson's Disease: A Systematic Review and Meta-Analysis

Rabab Rangwala et al. J Parkinsons Dis. 2023.

Abstract

Background: Swallowing impairment, including altered physiology and aspiration, occur across the progression of Parkinson's disease (PD). The phase of respiration during which a swallow is initiated has been linked to swallowing impairment and aspiration in cohorts with dysphagia following stroke and head and neck cancer treatment, but has been understudied in PD. If similar findings are shown in individuals with PD, the implications for swallowing assessment and treatment are significant.

Objective: The aim of this systematic review and meta-analysis of literature was to examine respiratory-swallow coordination measures and potential implications on swallowing physiology in individuals with PD.

Methods: An extensive search of 7 databases (PubMed, EMBASE, Central, Web of Science, ProQuest Dissertations & Theses, Scopus, and CINAHL) with predetermined search terms was conducted. Inclusion criteria were individuals with PD and the use of objective evaluations of respiratory-swallow coordination.

Results: Of the 13,760 articles identified, 11 met the inclusion criteria. This review supports the presence of atypical respiratory swallow patterning, respiratory pause duration and lung volume at swallow initiation in individuals with PD. The meta-analysis estimated an occurrence of 60% of non-expiration-expiration and 40% of expiration-expiration respiratory phase patterns surrounding swallowing.

Conclusion: Although this systematic review supports the occurrence of atypical respiratory-swallow coordination in individuals with PD, the evidence is limited by the variability in the methods of data acquisition, analysis, and reporting. Future research examining the impact of respiratory swallow coordination on swallowing impairment and airway protection using consistent, comparable, and reproducible methods and metrics in individuals with PD is warranted.

Keywords: Deglutition disorders; Parkinson’s disease; meta-analysis; respiration; systematic review.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Fig. 1
Fig. 1
The figure showcases the screening process using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) for determining the eleven articles included in this systematic review.
Fig. 2
Fig. 2
Pooled estimate of EX-EX respiratory phase pattern by groups (in proportion).
Fig. 3
Fig. 3
Pooled estimate of non-EX-EX respiratory phase pattern by groups (in proportion).
See this image and copyright information in PMC

References

    1. Pringsheim T, Jette N, Frolkis A, Steeves TDL (2014) The prevalence of Parkinson’s disease: A systematic review and meta-analysis. Mov Disord 29, 1583–1590. - PubMed
    1. Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J (2011) Epidemiology and etiology of Parkinson’s disease: A review of the evidence. Eur J Epidemiol 26, S1–S58. - PubMed
    1. Yang W, Hamilton JL, Kopil C, Beck JC, Tanner CM, Albin RL, Ray Dorsey E, Dahodwala N, Cintina I, Hogan P, Thompson T (2020) Current and projected future economic burden of Parkinson’s disease in the U.S. NPJ Parkinsons Dis 6, 15. - PMC - PubMed
    1. Davie CA (2008) A review of Parkinson’s disease. Br Med Bull 86, 109–127. - PubMed
    1. Kalia LV, Lang AE (2015) Parkinson’s disease. Lancet 386, 896–912. - PubMed

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