Progress and promise of alternative animal and non-animal methods in biomedical research
- PMID: 37394624
- DOI: 10.1007/s00204-023-03532-1
Progress and promise of alternative animal and non-animal methods in biomedical research
Erratum in
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Correction to: Progress and promise of alternative animal and non-animal methods in biomedical research.Arch Toxicol. 2023 Nov;97(11):3021. doi: 10.1007/s00204-023-03595-0. Arch Toxicol. 2023. PMID: 37665364 No abstract available.
Abstract
Cell culture and invertebrate animal models reflect a significant evolution in scientific research by providing reliable evidence on the physiopathology of diseases, screening for new drugs, and toxicological tests while reducing the need for mammals. In this review, we discuss the progress and promise of alternative animal and non-animal methods in biomedical research, with a special focus on drug toxicity.
Keywords: 3D cell culture; Brine Shrimp (Artemia salina); Fruit fly (Drosophila melanogaster); Galleria mellonella larvae; Roundworms (Caenorhabditis elegans); Zebrafish.
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
References
-
- Adamski Z, Bufo SA, Chowanski S et al (2019) Beetles as model organisms in physiological, biomedical and environmental studies—a review. Front Physiol 10:319. https://doi.org/10.3389/fphys.2019.00319 - DOI - PubMed - PMC
-
- Affleck JG, Walker VK (2019) Drosophila as a model for developmental toxicology: using and extending the drosophotoxicology model. Methods Mol Biol 1965:139–153. https://doi.org/10.1007/978-1-4939-9182-2_10 - DOI - PubMed
-
- Andersen ML, Winter L (2019) Animal models in biological and biomedical research—experimental and ethical concerns. An Acad Bras Cienc 91(suppl 1):e20170238. https://doi.org/10.1590/0001-3765201720170238 - DOI - PubMed
-
- Archer CR, Sargeant R, Basak J (2018) Characterization and validation of a human 3D cardiac microtissue for the assessment of changes in cardiac pathology. Sci Rep 8(1):10160. https://doi.org/10.1038/s41598-018-28393-y - DOI - PubMed - PMC
-
- Ates M, Demir V, Arslan Z et al (2015) Evaluation of alpha and gamma aluminum oxide nanoparticle accumulation, toxicity, and depuration in Artemia salina larvae. Environ Toxicol 30(1):109–118. https://doi.org/10.1002/tox.21917 - DOI - PubMed