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Multicenter Study
. 2024 Jan;131(1):99-108.
doi: 10.1111/1471-0528.17591. Epub 2023 Jul 2.

Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy: a multicentre cross-sectional study

Lara Terra  1 , Bernadette A M Heemskerk-Gerritsen  2 , Maarten J Beekman  1 , Ellen Engelhardt  1 , Marian J E Mourits  3 , Helena C van Doorn  4 , Joanna A de Hullu  5 , Constantijne H Mom  6 , Brigitte F M Slangen  7   8 , Katja N Gaarenstroom  9 , Marc van Beurden  10 , Jeanine E Roeters Van Lennep  11 , Eleonora B L van Dorst  12 , Lizet E van der Kolk  13 , J Margriet Collée  14 , Marijke R Wevers  15 , Margreet G E M Ausems  16 , Klaartje van Engelen  17 , Irma van de Beek  18 , Lieke P V Berger  19 , Christi J van Asperen  20 , Encarna B Gomez Garcia  21 , Angela H E M Maas  22 , Maartje J Hooning  2 , Anneke B Steensma  23 , Flora E van Leeuwen  1
Affiliations
Multicenter Study

Urinary incontinence more than 15 years after premenopausal risk-reducing salpingo-oophorectomy: a multicentre cross-sectional study

Lara Terra et al. BJOG. 2024 Jan.

Abstract

Objective: To study the impact of premenopausal risk-reducing salpingo-oophorectomy (RRSO), compared with postmenopausal RRSO, on urinary incontinence (UI) ≥10 years later.

Design: Cross-sectional study, nested in a nationwide cohort.

Setting: Multicentre in the Netherlands.

Population: 750 women (68% BRCA1/2 pathogenic variant carriers) who underwent either premenopausal RRSO (≤45 years, n = 496) or postmenopausal RRSO (≥54 years, n = 254). All participants were ≥55 years at the time of the study.

Methods: Urinary incontinence was assessed by the urinary distress inventory-6 (UDI-6); a score ≥33.3 indicated symptomatic UI. The incontinence impact questionnaire short form (IIQ-SF) was used to assess the impact on women's health-related quality of life (HR-QoL). Differences between groups were analysed using regression analyses adjusting for current age and other confounders.

Main outcome measures: Differences in UDI-6 scores and IIQ-SF scores between women with a premenopausal and a postmenopausal RRSO.

Results: Women in the premenopausal RRSO group had slightly higher UDI-6 scores compared with women in the postmenopausal RRSO group (P = 0.053), and their risk of symptomatic UI was non-significantly increased (odds ratio [OR] 2.1, 95% confidence interval [95% CI] 0.93-4.78). A premenopausal RRSO was associated with a higher risk of stress UI (OR 3.5, 95% CI 1.2-10.0) but not with urge UI. The proportions of women with a significant impact of UI on HR-QoL were similar in the premenopausal and postmenopausal RRSO groups (10.4% and 13.0%, respectively; P = 0.46).

Conclusions: More than 15 years after premenopausal RRSO, there were no significant differences in overall symptomatic UI between women with a premenopausal and those with a postmenopausal RRSO.

Keywords: BRCA pathogenic variant carriers; health-related quality of life; menopause; premenopausal RRSO; preventive bilateral salpingo-oophorectomy; stress incontinence; urge incontinence.

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References

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