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. 2023 Jul 15;37(9):1481-1486.
doi: 10.1097/QAD.0000000000003577. Epub 2023 Apr 13.

No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands

Myrthe L Verburgh  1   2   3   4 , Marc van der Valk  1   2   5 , Bart J A Rijnders  6 , Peter Reiss  1   2   4   7 , Ferdinand W N M Wit  1   2   5
Affiliations

No association between use of tenofovir disoproxil fumarate, etravirine, or integrase-strand transfer inhibitors and acquisition or severe outcomes of SARS-CoV-2 infection in people with HIV in the Netherlands

Myrthe L Verburgh et al. AIDS. .

Abstract

In two Dutch observational cohorts of people with HIV, the use of TDF, ETR, or INSTIs was not independently associated with either the risk of incident SARS-CoV-2 infection or severe COVID-19 outcomes, as was suggested by previous observational and molecular docking studies. Our findings do not support a strategy of modifying antiretroviral therapy to include these agents to protect against SARS-CoV-2 infection and severe COVID-19 outcomes.

Trial registration: ClinicalTrials.gov NCT01466582.

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Conflict of interest statement

M. van der Valk through his institution has received independent scientific grant support and consultancy fees from Gilead Sciences, MSD, and ViiV Healthcare, for which honoraria were all paid to his institution. B.R. has received research grants from Gilead, research grants from Merck Sharp and Dohme, and honoraria from Jansen-Cilag, BMS, Pfizer, and ViiV. P.R. through his institution has received independent scientific grant support from Gilead Sciences, Janssen Pharmaceuticals Inc, Merck & Co, and ViiV Healthcare, and has served on scientific advisory boards for Gilead Sciences, ViiV Healthcare, and Merck & Co honoraria for which were all paid to his institution. F.W.N.M.W. has served on scientific advisory boards for ViiV Healthcare and Gilead sciences. M.L.V. declares no competing interests.

The AGEhIV COVID-19 substudy was supported in part through an investigator-initiated study grant from ViiV Healthcare. The parent AGEhIV Cohort Study was supported by The Netherlands Organization for Health Research and Development [ZonMW, grant number 30002000] and AIDS Fonds [grant number 2009063], and in part by unrestricted research grants from Gilead Sciences; ViiV Healthcare; Janssen Pharmaceuticals N.V.; and Merck Sharp & Dohme Corp. The ATHENA cohort is managed by the HIV Monitoring Foundation (Stichting hiv monitoring) and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Center for Infectious Disease Control of the National Institute for Public Health and the Environment.

Informed consent was obtained from all participants. The AGEhIV cohort study was approved by the ethics committee of the Amsterdam UMC, location AMC, and is registered at www.clinicaltrials.gov (NCT01466582). The ATHENA cohort was approved by the institutional review boards of all participating HIV treatment centers.

Comment in

References

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