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. 2023 Oct;149(13):11541-11547.
doi: 10.1007/s00432-023-05030-4. Epub 2023 Jul 3.

Demographic disparities in trend of gynecological cancer in the United States

Sishir Doddi  1 , Oscar Salichs  2 , Mahika Mushuni  3 , Siddharth Kunte  4
Affiliations

Demographic disparities in trend of gynecological cancer in the United States

Sishir Doddi et al. J Cancer Res Clin Oncol. 2023 Oct.

Abstract

Purpose: This study aimed to analyze the age-adjusted mortality rates (AAMR) per 100,000 for gynecological cancer-related deaths in the United States from 1999 to 2020. We compare trends by different demographic groups to identify significant disparities in these rates between populations within the United States.

Methods: The National Cancer Institute's Joinpoint Regression Program was used to calculate the average Annual Percent Change (AAPC) to identify trends over the study period using data from the CDC Wonder database, which comprises of demographic information for all causes of mortality in the United States from death certificate records.

Results: From 1999 to 2020, the African American population exhibited a significant downtrend (AAPC, -0.8% [95% CI, - 1.0% to - 0.6%]; p < 0.01), while the white population also demonstrated a notable downtrend (AAPC, - 1.0% [95% CI, - 1.2% to - 0.8%]; p < 0.01). Similarly, the AI/AN population experienced a decline (AAPC, - 1.6% [95% CI, - 2.4% to - 0.9%]; p < 0.01). The AAPI population did not observe a significant trend (AAPC, - 0.2% [95% CI, - 0.5% to 0.5%]; p = 0.127). In addition, the Hispanic/LatinX population experiencing a lower rate of decline compared to non-Hispanics (p = 0.025).

Conclusions: We found that the AI/AN population to observe the greatest downtrend in mortality rates, while the AAPI observed the least and that the African American population observed a smaller downtrend when compared to the white population. In addition, the Hispanic/LatinX community are significantly being underserved by developing therapies compared to the non-Hispanic/LatinX population. These findings provide valuable insights into the impact of gynecological cancers on specific demographic groups, emphasizing the urgency of targeted interventions to address disparities and improve outcomes.

Keywords: Disparities; Gynecological cancers; Mortality rate; Mortality trends.

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Conflict of interest statement

No conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
AAMR due to female gynecological cancer between 1999 and 2020 by race. AAMR per 100,000 between 1999 and 2020 separated by race: American Indian or Alaska Native (AI/AN), Asian or Pacific Islander (AAPI), Black or African American, and white. Significant trends are APC values with an asterisk
Fig. 2
Fig. 2
AAMR due to female gynecological cancer between 1999 and 2020 by ethnic group. AAMR per 100,000 between 1999 and 2020 separated by ethnic group. Significant trends are APC values with an asterisk
Fig. 3
Fig. 3
a AAMR due to Female Gynecological Cancer by state in 1999. b AAMR due to Female Gynecological by state in 2020
See this image and copyright information in PMC

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