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. 2023 Oct;43(10):3681-3693.
doi: 10.1007/s10792-023-02778-z. Epub 2023 Jul 3.

Clinical characteristics of intermediate uveitis in adults according to criteria of the SUN working group

Berru Yargi-Ozkocak  1 , Cigdem Altan  2 , Burcu Kemer-Atik  2 , Berna Basarir  2
Affiliations

Clinical characteristics of intermediate uveitis in adults according to criteria of the SUN working group

Berru Yargi-Ozkocak et al. Int Ophthalmol. 2023 Oct.

Abstract

Purpose: To analyse the clinical characteristics of adult patients with pars planitis (PP-IU), non-pars planitis (NPP-IU) and multiple sclerosis-associated intermediate uveitis (MS-IU) and distinguish between groups.

Methods: Seventy-three adult patients with intermediate uveitis (IU) reviewed retrospectively and divided as PP-IU, NPP-IU and MS-IU according to 'The standardization of uveitis nomenclature working group classification criteria.' Demographic and clinical characteristics, OCT and fluorescein angiography (FA) findings, complications and treatments were recorded.

Results: A total of 134 eyes of 73 patients were included, and 42 of the patients were classified as PP-IU, 12 as NPP-IU, and 19 as MS-IU. If a patient presenting with blurred vision, or tent-shaped vitreous band/snowballs/snowbank on examination, or vascular leakage on FA and accompanying neurological symptoms, the frequency of demyelinating plaque detection on cranial MRI and the risk of MS-IU increased. Mean BCVA was increased from 0.22 ± 0.30 logMAR to 0.19 ± 0.31 logMAR (p = 0.021). Gender, initial BCVA, snowbank formation, disc oedema and periphlebitis on examination, and disc leakage/occlusion on FA were found predictive of decreased BCVA at final visit (p < 0.05).

Conclusions: The clinical features of these three groups are similar, some features that can guide the differential diagnosis. It may be recommended to periodically evaluate "suspicious" patients with MRI for MS.

Keywords: Intermediate uveitis; Multiple sclerosis; Non-pars planitis; Pars planitis; SUN classification.

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References

    1. Bloch-Michel E, Nussenblatt RB (1987) International Uveitis study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol 103(2):234–235 - DOI - PubMed
    1. Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of Uveitis Nomenclature Working G: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140(3):509–516 - DOI - PubMed
    1. Standardization of uveitis nomenclature working G: Development of Classification Criteria for the Uveitides. Am J Ophthalmol 2021, 228:96–105
    1. Donaldson MJ, Pulido JS, Herman DC, Diehl N, Hodge D (2007) Pars planitis: a 20-year study of incidence, clinical features, and outcomes. Am J Ophthalmol 144(6):812–817 - DOI - PubMed
    1. Sancho L, Kramer M, Koriat A, Eiger-Moscovich M, Sharon Y, Amer R (2019) Complications in intermediate uveitis: prevalence, time of onset, and effects on vision in short-term and long-term follow-up. Ocul Immunol Inflamm 27(3):447–455 - DOI - PubMed

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