Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 16:14:1132342.
doi: 10.3389/fendo.2023.1132342. eCollection 2023.

Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention

Yali Zheng  1 , Ni Yang  1 , Yueshan Pang  1 , Yanju Gong  1 , Hong Yang  1   2 , Weijun Ding  1 , Hongya Yang  1
Affiliations

Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention

Yali Zheng et al. Front Endocrinol (Lausanne). .

Abstract

Introduction: A systematic review analysis was used to assess the profile of mitochondrial involvement in adipose tissue regulation and potential reagents to intervene in obesity through the mitochondrial pathway.

Methods: Three databases, PubMed, Web of Science, and Embase, were searched online for literature associated with mitochondria, obesity, white adipose tissue, and brown adipose tissue published from the time of their creation until June 22, 2022, and each paper was screened.

Results: 568 papers were identified, of which 134 papers met the initial selection criteria, 76 were selected after full-text review, and 6 were identified after additional searches. A full-text review of the included 82 papers was performed.

Conclusion: Mitochondria play a key role in adipose tissue metabolism and energy homeostasis, including as potential therapeutic agents for obesity.

Keywords: UCP1; brown adipose tissue (BAT); mitochondria; obesity; white adipose tissue (WAT).

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The flow of the literature retrieval.
Figure 2
Figure 2
Mitochondria monitor the thermogenesis of brown and activate the browning of WAT. Sirtuin 3 (SIRT3); cAMP response element-binding protein (CREB); peroxisome proliferator-activated receptor-γ cofactor 1α (PGC1α); uncoupling protein-1 (UCP1); optic atrophy 1 (OPA1); hypoxia-inducible factor-1α (HIF-1α); peroxisome proliferator-activated receptor gamma (PPARγ); sirtuin 1 (SIRT1); AMP-activated protein kinase (AMPK); mitochondrial transcription factor A (TFAM).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sahu B, Tikoo O, Pati B, Senapati U, Bal NC. Role of distinct fat depots in metabolic regulation and pathological implications. Rev Physiol Biochem Pharmacol (2023) 186:135–76. doi: 10.1007/112_2022_73 - DOI - PubMed
    1. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol (2014) 10(1):24–36. doi: 10.1038/nrendo.2013.204 - DOI - PubMed
    1. Betz MJ, Enerback S. Human brown adipose tissue: what we have learned so far. Diabetes (2015) 64(7):2352–60. doi: 10.2337/db15-0146 - DOI - PubMed
    1. Ali Khan A, Hansson J, Weber P, Foehr S, Krijgsveld J, Herzig S, et al. . Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines*. Mol Cell Proteomics (2018) 17(12):2358–70. doi: 10.1074/mcp.RA118.000704 - DOI - PMC - PubMed
    1. Ernster L, Schatz G. Mitochondria: a historical review. J Cell Biol (1981) 91(3 Pt 2):227s–55s. doi: 10.1083/jcb.91.3.227s - DOI - PMC - PubMed

Publication types