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Review
. 2023;26(7):732-737.
doi: 10.22038/IJBMS.2023.66563.14606.

Potential use of angiotensin receptor blockers in skin pathologies

Keshvad Hedayatyanfard  1   2 , Azadeh Khalili  1 , Hosein Karim  2   3 , Soren Nooraei  4 , Ehsan Khosravi  5 , Nazgol-Sadat Haddadi  6 , Ahmad-Reza Dehpour  7 , Gholamreza Bayat  1
Affiliations
Review

Potential use of angiotensin receptor blockers in skin pathologies

Keshvad Hedayatyanfard et al. Iran J Basic Med Sci. 2023.

Abstract

Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT1R and AT2R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT1R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT2R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-6. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.

Keywords: Angiotensin II; Cancer; Keloid; Scar; Skin disease; Wound healing.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

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References

    1. Drosten M, Lechuga C, Barbacid MJO. Ras signaling is essential for skin development. Oncogene. 2014;33:2857–2865. - PubMed
    1. Silva IMS, Assersen KB, Willadsen NN, Jepsen J, Artuc M, Steckelings UMJED. The role of the renin-angiotensin system in skin physiology and pathophysiology. Exp Dermatol. 2020;29:891–901. - PubMed
    1. Santos RAS, Oudit GY, Verano-Braga T, Canta G, Steckelings UM, Bader MJAJoP-H, et al. The renin-angiotensin system: Going beyond the classical paradigms. Am J Physiol Heart Circ Physiol. 2019;316:H958–H970. - PMC - PubMed
    1. Hedayatyanfard K, Haddadi NS, Ziai SA, Karim H, Niazi F, Steckelings UM, et al. The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation. Exp Dermatol. 2020;29:902–909. - PubMed
    1. Ellis S, Lin EJ, Tartar DJCdr. Immunology of wound healing. Curr Dermatol Rep. 2018;7:350–358. - PMC - PubMed

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