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. 2023 Jun 30;96(2):159-169.
doi: 10.59249/KYDF6093. eCollection 2023 Jun.

Exacerbation of Renal, Cardiovascular, and Respiratory Outcomes Associated with Changes in Climate

David Baraghoshi  1 , Cameron Niswander  2   3 , Matthew Strand  1 , Stefan Wheat  4 , Julie Ramstetter  5 , Nicholas Stoll  3 , Jacob Fox  2   3 , Katherine A James  3
Affiliations

Exacerbation of Renal, Cardiovascular, and Respiratory Outcomes Associated with Changes in Climate

David Baraghoshi et al. Yale J Biol Med. .

Abstract

Exposure to environmental variables including declining air quality and increasing temperatures can exert detrimental effects on human health including acute exacerbations of chronic diseases. We aim to investigate the association between these exposures and acute health outcomes in a rural community in Colorado. Meteorological and adult emergency department visit data were retrospectively collected (2013-2017); for asthma outcomes, additional data were available (2003-2017). Daily environmental exposure data included PM10, maximum daily temperature (MDT), and mean humidity and precipitation. Total daily counts of emergency department (ED) diagnoses for myocardial infarction, congestive heart failure, urolithiasis, and exacerbation of chronic obstructive pulmonary disease (COPD) and asthma, were calculated during the study period. Time series models using generalized estimating equations were fit for each disease and included all four environmental factors. Between 2013 and 2017, asthma and COPD exacerbation accounted for 30.8% and 25.4% of all ED visits (n=5,113), respectively. We found that for every 5˚C increase in MDT, the rate of urolithiasis visits increased by 13% (95% CI: 2%, 26%) and for every 10μg/m3 increase in 3-day moving average PM10, the rate of urolithiasis visits increased by 7% (95% CI: 1%, 13%). The magnitude of association between 3-day moving average PM10 and rate of urolithiasis visits increased with increasing MDT. The rate of asthma exacerbation significantly increased as 3-day, 7-day, and 21-day moving average PM10 increased. This retrospective study on ED visits is one of the first to investigate the impact of several environmental exposures on adverse health outcomes in a rural community. Research into mitigating the negative impacts of these environmental exposures on health outcomes is needed.

Keywords: air quality; asthma; climate; nephrolithiasis; particulate matter; urolithiasis.

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Figures

Figure 1
Figure 1
The relationship between number of emergency room visits for asthma exacerbations and PM10 (expressed as rate ratio (RR) with error bars representing 95% Confidence Intervals) across lag structures and moving averages (MA), during the 15-year study period.
See this image and copyright information in PMC

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