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. 2023 Jun 26:16:2171-2188.
doi: 10.2147/JPR.S407050. eCollection 2023.

A Bibliometric Analysis of Exosomes Therapy in the Treatment of Osteoarthritis from 2012 to 2022

Zhi Qiang Luo #  1 , Biao Zhou #  2   3 , Hui Xiong  1
Affiliations

A Bibliometric Analysis of Exosomes Therapy in the Treatment of Osteoarthritis from 2012 to 2022

Zhi Qiang Luo et al. J Pain Res. .

Abstract

Purpose: Osteoarthritis (OA) is a common clinical disease characterized by the destruction of articular cartilage, subchondral ossification, cystic degeneration and osteophyte formation. Recently, more and more scholars draw attention to exosomes in the field of OA, and exciting breakthroughs have been achieved in recent years. However, bibliometric analysis of the literature in this research field is lacking. Considering its potential in treatment of OA, this article aimed to analyze the research status and identify future hotspots of exosomes in osteoarthritis in recent 10 years by bibliometrics tools.

Methods: Relevant publications in this field from 2012 to 2022 was retrieved from the Web of Science core collection database (WOSSCC). And we used Vosviewers, CiteSpace, an online analysis platform and the R package "Bibliometrix" for bibliometric analysis.

Results: A total of 484 publications (including 319 articles and 165 reviews) from 51 countries, 720 institutions, were included in this study. IRCCS Ist Ortoped Galeazzi, Shanghai Jiao Tong University, and Sun Yat-sen University are the leading research institutions in this field. International Journal of Molecular Sciences contributed the largest number of articles, and Osteoarthritis and Cartilage is the most co-cited journal. Of the 2664 scholars who participated in the study, Ragni E, De Girolamo L, Orfei CP, and Colombini A had the largest number of articles. Zhang, SP is the most co-cited author. "Mesenchymal stem cell", "biomaterials", "Inflammation" and "regenerative medicine" are the keywords in the research.

Conclusion: This is the first bibliometric analysis of exosomes in osteoarthritis. We explored current research status in recent years and identified frontiers and hot spots in this research field. We highlight the significant roles of mesenchymal stem cell-derived exosomes (MSC-Exos) in the treatment of osteoarthritis, and identified exosomal biomaterials as frontier in this research domain, which can provide reference for the researchers who focus on this research field.

Keywords: CiteSpace; R package “bibliometrix”; VOSviewer; bibliometric analysis; exosomes; osteoarthritis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flowchart of literature identification and analysis process.
Figure 2
Figure 2
(A) The visualization of institutions cooperation networks based on CiteSpace. (B) Top 5 institutions’ production over time. (C) Map of authors’ cooperative relationship and (D) visualization of journals on the research of exosomes in osteoarthritis based on VOSviewer.
Figure 3
Figure 3
(A) Network map of journals that were co-cited in more than 20 citations. (B) Top 5 journals’ publication overtime. (C) The dual-map overlay of journals related to exosomes in orthopedics.
Figure 4
Figure 4
(A) Network map of citation analysis of documents with more than 5 citations. (B) Network map of co-citation analysis of references. (C) Top 25 references with strongest citation bursts of publications regarding exosomes in osteoarthritis.
Figure 5
Figure 5
(A) Top 15 keywords with the strongest citation bursts based on Citespace. (B) overlay visualization of the keyworks network based on Vosviewer. (C) Three-field plot of the Keywords analysis base on R package “bibliometrix” and (D) The timeline view of keywords conducted by CiteSpace.
Figure 6
Figure 6
(A) Annual outputs of publications regarding exosomes in osteoarthritis field. (B) TOP 20 Corresponding Author’s countries that produced the largest number of literature. (C) The overlay visualization map of country co-authorship analysis conducted by VOSviewer. (D) The international cooperation analysis among different countries. (E) The geographical network map of exosomes in osteoarthritis.
Figure 7
Figure 7
(A) Network visualization diagram of the co-cited authors regarding exosomes in osteoarthritis.(B) Top 10 authors’ production over time.
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References

    1. Fransen M, Bridgett L, March L, et al. The epidemiology of osteoarthritis in Asia. Int J Rheum Dis. 2011;14(2). doi:10.1111/j.1756-185X.2011.01608.x - DOI - PubMed
    1. Safiri S, Kolahi AA, Smith E, et al. Global, regional and national burden of osteoarthritis 1990–2017: a systematic analysis of the global burden of disease study 2017. Ann Rheum Dis. 2020;79(6). doi:10.1136/annrheumdis-2019-216515 - DOI - PubMed
    1. Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104(2):293–311. doi:10.1016/j.mcna.2019.10.007 - DOI - PubMed
    1. Cosenza S, Toupet K, Maumus M, et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics. 2018;8(5). doi:10.7150/thno.21072 - DOI - PMC - PubMed
    1. Gurunathan S, Kang MH, Jeyaraj M, Qasim M, Kim JH. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8(4). doi:10.3390/cells8040307 - DOI - PMC - PubMed