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. 2023 Jun 16:14:1173251.
doi: 10.3389/fphar.2023.1173251. eCollection 2023.

Bibliometric analysis and visualization of transdermal drug delivery research in the last decade: global research trends and hotspots

Xinghan Chen  1   2 , Haitao Xiao  2 , Xiujun Shi  1 , Qiao Zhao  1 , Xuewen Xu  2 , Ping Fan  3 , Dongqin Xiao  1
Affiliations

Bibliometric analysis and visualization of transdermal drug delivery research in the last decade: global research trends and hotspots

Xinghan Chen et al. Front Pharmacol. .

Abstract

Background: Transdermal delivery has become a crucial field in pharmaceutical research. There has been a proliferation of innovative methods for transdermal drug delivery. In recent years, the number of publications regarding transdermal drug delivery has been rising rapidly. To investigate the current research trends and hotspots in transdermal drug delivery, a comprehensive bibliometric analysis was performed. Methods: An extensive literature review was conducted to gather information on transdermal drug delivery that had been published between 2003 and 2022. The articles were obtained from the Web of Science (WOS) and the National Center for Biotechnology Information (NCBI) databases. Subsequently, the collected data underwent analysis and visualization using a variety of software tools. This approach enables a deeper exploration of the hotspots and emerging trends within this particular research domain. Results: The results showed that the number of articles published on transdermal delivery has increased steadily over the years, with a total of 2,555 articles being analyzed. The most frequently cited articles were related to the optimization of drug delivery and the use of nanotechnology in transdermal drug delivery. The most active countries in the field of transdermal delivery research were the China, United States, and India. Furthermore, the hotspots over the past 2 decades were identified (e.g., drug therapy, drug delivery, and pharmaceutical preparations and drug design). The shift in research focus reflects an increasing emphasis on drug delivery and control release, rather than simply absorption and penetration, and suggests a growing interest in engineering approaches to transdermal drug delivery. Conclusion: This study provided a comprehensive overview of transdermal delivery research. The research indicated that transdermal delivery would be a rapidly evolving field with many opportunities for future research and development. Moreover, this bibliometric analysis will help researchers gain insights into transdermal drug delivery research's hotspots and trends accurately and quickly.

Keywords: bibliometric analysis; biclustering analysis; hotspot; transdermal delivery; visualization.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor HD declared a shared affiliation with the authors XC, HX, XX, PF at the time of review.

Figures

FIGURE 1
FIGURE 1
Flow chart of inclusion and exclusion.
FIGURE 2
FIGURE 2
Growth of publications on transdermal drug delivery (2003–2022).
FIGURE 3
FIGURE 3
Geographical distribution of retrieved articles in transdermal drug delivery (2003–2022).
FIGURE 4
FIGURE 4
The growth trends of the top 10 nations/regions in transdermal drug delivery (2003–2022).
FIGURE 5
FIGURE 5
The network map of country/region’ cooperation.
FIGURE 6
FIGURE 6
Cluster density visualization map of institutions on transdermal drug delivery (2003–2022).
FIGURE 7
FIGURE 7
Density visualization map of journals on transdermal drug delivery (2003–2022).
FIGURE 8
FIGURE 8
The top 25 burst words from 2003 to 2022.
FIGURE 9
FIGURE 9
Matrix visualization of major MeSH terms/MeSH subheading terms of articles on transdermal drug delivery.
FIGURE 10
FIGURE 10
Mountain visualization of major MeSH terms/MeSH subheading terms of articles on transdermal drug delivery.
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