Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

doi:10.1007/s13340-023-00631-3

. 2023 Apr 19;14(3):280-287.

doi: 10.1007/s13340-023-00631-3. eCollection 2023 Jul.

Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

Daisuke Sugawara¹, Eishi Makita¹, Misa Matsuura¹, Hiroaki Sato¹, Tomoyuki Kuwata², Ko Ichihashi¹

Affiliations

¹ Department of Pediatrics, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.
² Department of Obstetrics and Gynecology, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.

PMID: 37397905
PMCID: PMC10307751
DOI: 10.1007/s13340-023-00631-3

Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

Daisuke Sugawara et al. Diabetol Int. 2023.

. 2023 Apr 19;14(3):280-287.

doi: 10.1007/s13340-023-00631-3. eCollection 2023 Jul.

Authors

Daisuke Sugawara¹, Eishi Makita¹, Misa Matsuura¹, Hiroaki Sato¹, Tomoyuki Kuwata², Ko Ichihashi¹

Affiliations

¹ Department of Pediatrics, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.
² Department of Obstetrics and Gynecology, Saitama Medical Center Jichi Medical University, 1-847 Amanuma-Cho, Saitama, 330-8503 Japan.

PMID: 37397905
PMCID: PMC10307751
DOI: 10.1007/s13340-023-00631-3

Abstract

Background: Maternal hyperglycemia, obesity, and hypertension with gestational diabetes mellitus (GDM) are risk factors for infant complications. This study aimed to investigate maternal factors and glycemic control indicators that affect infant complications in GDM.

Methods: We conducted a retrospective cohort study including 112 mothers with GDM and their infants. Multivariate logistic regression analysis was used to investigate the variables associated with good and adverse infant outcomes. We determined the cutoff values of variables that showed a significant difference in the multivariate logistic regression analysis for predicting infant complications by performing receiver operating characteristic curve analysis.

Results: In the multivariate logistic regression analysis, prepregnancy BMI and GA in the third trimester were significantly related to good and adverse infant outcomes (adjusted odds ratios [aORs], 1.62; 95% CIs 1.17-2.25, p = 0.003 and aORs, 2.77; 95% CIs 1.15-6.64, p = 0.022, respectively). The cutoff values for prepregnancy BMI and GA in the third trimester were 25.3 kg/m2 and 13.5%, respectively.

Conclusions: The importance of weight control before pregnancy and the usefulness of GA in the third trimester to predict infant complications were suggested in this study.

Keywords: Body mass index; Gestational diabetes mellitus; Glycated albumin; Glycated hemoglobin; Infant complication.

© The Japan Diabetes Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Conflict of interest statement

Conflict of interestThe authors declare no conflicts of interest.

Figures

**Fig. 1**
The flowchart of this study. GDM, gestational diabetes mellitus

**Fig. 2**
The cutoff values of prepregnancy BMI and GA in the third trimester in women with gestational diabetes mellitus for predicting perinatal outcomes via receiver operating characteristic curve analysis. *BMI* body mass index; GA glycated albumin

See this image and copyright information in PMC

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[1] Buchanan TA, Kitzmiller JL. Metabolic interactions of diabetes and pregnancy. Annu Rev Med. 1994;45:245–260. doi: 10.1146/annurev.med.45.1.245. - DOI - PubMed

[2] Buchanan TA, Kitzmiller JL. Metabolic interactions of diabetes and pregnancy. Annu Rev Med. 1994;45:245–260. doi: 10.1146/annurev.med.45.1.245. - DOI - PubMed

[3] American Diabetes Association Glycemic targets: standards of medical care in diabetes. Diabet Care. 2020;43:66–76. doi: 10.2337/dc20-S006. - DOI - PubMed

[4] American Diabetes Association Glycemic targets: standards of medical care in diabetes. Diabet Care. 2020;43:66–76. doi: 10.2337/dc20-S006. - DOI - PubMed

[5] Shimizu I, Hiramatsu Y, Omori Y, Nakabayashi M, J.G.A. (Japan Glycated Albumin) Study Group Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan (Japan glycated albumin study group: study 2) Ann Clin Biochem. 2018;55:639–646. doi: 10.1177/0004563218763695. - DOI - PubMed

[6] Shimizu I, Hiramatsu Y, Omori Y, Nakabayashi M, J.G.A. (Japan Glycated Albumin) Study Group Comparison of HbA1c and glycated albumin as a control marker for newborn complications in diabetic women in a multicentre study in Japan (Japan glycated albumin study group: study 2) Ann Clin Biochem. 2018;55:639–646. doi: 10.1177/0004563218763695. - DOI - PubMed

[7] Zhang X, Wei Y, Fan L, Zhao Y, Li Y, Liu Y, et al. A multicenter all-inclusive prospective study on the relationship between glycemic control markers and maternal and neonatal outcomes in pregnant women. J Matern Fetal Neonatal Med. 2021;34:3154–3161. doi: 10.1080/14767058.2019.1678139. - DOI - PubMed

[8] Zhang X, Wei Y, Fan L, Zhao Y, Li Y, Liu Y, et al. A multicenter all-inclusive prospective study on the relationship between glycemic control markers and maternal and neonatal outcomes in pregnant women. J Matern Fetal Neonatal Med. 2021;34:3154–3161. doi: 10.1080/14767058.2019.1678139. - DOI - PubMed

[9] Kohzuma T, Tao X, Koga M. Glycated albumin as biomarker: evidence and its outcomes. J Diabetes Complications. 2021;35:108040. doi: 10.1016/j.jdiacomp.2021.108040. - DOI - PubMed

[10] Kohzuma T, Tao X, Koga M. Glycated albumin as biomarker: evidence and its outcomes. J Diabetes Complications. 2021;35:108040. doi: 10.1016/j.jdiacomp.2021.108040. - DOI - PubMed

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Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

Affiliations

Prepregnancy body mass index and glycated albumin in the third trimester may predict infant complications in gestational diabetes mellitus: a retrospective cohort study

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