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Review
. 2023 Nov;48(11):101918.
doi: 10.1016/j.cpcardiol.2023.101918. Epub 2023 Jul 2.

Baxdrostat: A Novel Aldosterone Synthase Inhibitor for Treatment Resistant Hypertension

Sonia Dogra  1 , Swara Shah  1 , Lucas Gitzel  1 , Bharani Pusukur  1 , Aayushi Sood  2 , Apurva V Vyas  3 , Rahul Gupta  4
Affiliations
Review

Baxdrostat: A Novel Aldosterone Synthase Inhibitor for Treatment Resistant Hypertension

Sonia Dogra et al. Curr Probl Cardiol. 2023 Nov.

Abstract

Hypertension is a global epidemic, affecting around 30.4% of the population and being the leading preventable risk factor for death. Despite the availability of numerous antihypertensive agents, less than 20% of individuals have their blood pressure controlled. Resistant hypertension poses a challenge, but a new class of medication, aldosterone synthase inhibitors (ASI), shows promise. ASI reduces aldosterone production by inhibiting aldosterone synthase. This review article focuses on Baxdrostat, a highly potent ASI currently in phase 3 trials. It discusses the drug's biochemical pathway, efficacy trials in animals and humans, and its potential in uncontrolled hypertension, chronic kidney disease, and primary aldosteronism.

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Conflict of interest statement

Declaration of Competing Interest 1) All authors have participated in the work and have reviewed and agree with the content of the article; 2) None of the article contents are under consideration for publication in any other journal or have been published in any journal; 3) No portion of the text has been copied from other material in the literature; 4) I am aware that it is the authors responsibility to obtain permission for any figures or tables reproduced from any prior publications, and to cover fully any costs involved. Every author listed contributed to our work in a substantial manner. Each author's contribution is as listed. 1) Conception and design: Sonia Dogra, Rahul Gupta; 2) Drafting of the manuscript and revising it critically for important intellectual content: Sonia Dogra, Swara Shah, Lucas Gitzel, Bharani Pusukur, Aayushi Sood, Apurva Vyas, Rahul Gupta; 3) Final approval of the manuscript submitted: Apurva Vyas, Rahul Gupta.

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