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Editorial
. 2023 Nov;84(5):447-448.
doi: 10.1016/j.eururo.2023.06.017. Epub 2023 Jul 1.

A Step Closer to Predicting Progression After Bacillus Calmette-Guérin Immunotherapy in High-risk Non-muscle-invasive Bladder Cancer

Madhuri Koti  1 , D Robert Siemens  2
Affiliations
Editorial

A Step Closer to Predicting Progression After Bacillus Calmette-Guérin Immunotherapy in High-risk Non-muscle-invasive Bladder Cancer

Madhuri Koti et al. Eur Urol. 2023 Nov.

Abstract

Treatment-naïve tumors from patients who then experience recurrence or progression after bacillus Calmette-Guérin (BCG) therapy exhibit elevated expression of genes associated with basal differentiation and immune suppression. Three tumor molecular subtypes have been associates with distinct clinical outcomes and will allow early identification of patients unlikely to respond to BCG immunotherapy.

Trial registration: ClinicalTrials.gov NCT05538663.

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