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. 2023 Sep;45(9):2469-2477.
doi: 10.1002/hed.27450. Epub 2023 Jul 4.

Long-term patient-reported outcomes after reconstructive surgery for head and neck cancer: A systematic review

Joep A F van Rooij  1 , Jantien Roubos  2 , Noëlle J M C Vrancken Peeters  2 , Bianca F M Rijken  2 , Eveline M L Corten  2 , Marc A M Mureau  2
Affiliations

Long-term patient-reported outcomes after reconstructive surgery for head and neck cancer: A systematic review

Joep A F van Rooij et al. Head Neck. 2023 Sep.

Abstract

Current literature on reconstruction after head and neck cancer (HNC) focusses on short-term patient-reported outcomes (PROs), while there is a need for knowledge on long-term consequences. Embase, Medline, Web of Science, and Cochrane were searched for studies on health-related quality of life (HRQoL) after HNC reconstruction, using validated PROMs in at least 50 patients, and a follow-up of more than 1 year. Thirty studies were included, comprising 2358 patients with a follow-up between one and 10 years. The most used questionnaire was the UW-QoL v4. Reconstructive surgery was generally followed by diminished oral function, worsened by radiotherapy. Patients experienced anxiety and fear of cancer recurrence. However, there was a progressive decrease in pain over time with some flaps having more favorable HRQoL outcomes. Age and bony tumor involvement were not related to postoperative HRQoL. These results may lead to better patient counseling and expectation management of HNC patients.

Keywords: head and neck cancer; patient-reported outcome measures; quality of life; reconstructive surgery; systematic review.

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References

REFERENCES

    1. Chow LQM. Head and neck cancer. N Engl J Med. 2020;382(1):60-72. doi:10.1056/NEJMra1715715
    1. Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V. Reprint of “squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up”. Oral Oncol. 2021;113:105042. doi:10.1016/j.oraloncology.2020.105042
    1. Dahill A, Al-Nakishbandi H, Cunningham KB, Humphris GM, Lowe D, Rogers SN. Loneliness and quality of life after head and neck cancer. Br J Oral Maxillofac Surg. 2020;58(8):959-965. doi:10.1016/j.bjoms.2020.04.041
    1. Buga S, Banerjee C, Salman J, Cangin M, Zachariah F, Freeman B. Supportive Care for the Head and Neck Cancer Patient. Cancer Treat Res. 2018;174:249-270. doi:10.1007/978-3-319-65421-8_15
    1. Cracchiolo JR, Klassen AF, Young-Afat DA, et al. Leveraging patient-reported outcomes data to inform oncology clinical decision making: introducing the FACE-Q head and neck cancer module. Cancer. 2019;125(6):863-872. doi:10.1002/cncr.31900

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