Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;45(9):2303-2312.
doi: 10.1002/hed.27437. Epub 2023 Jul 5.

Nodal metastasis in surgically treated laryngeal squamous cell carcinoma

Aman Prasad  1 , Ryan M Carey  2 , Kush Panara  3 , Karthik Rajasekaran  3 , Steven B Cannady  3 , Jason G Newman  4 , Jason A Brant  3 , Robert M Brody  3
Affiliations

Nodal metastasis in surgically treated laryngeal squamous cell carcinoma

Aman Prasad et al. Head Neck. 2023 Sep.

Abstract

Background: Management of the neck in laryngeal squamous cell carcinoma (LSCC) is essential to oncologic control and survival. We aim to describe patterns and rates of clinical/pathologic lymph node disease, elective neck dissection (END), and occult lymph node metastasis (LNM) in patients with surgically-managed LSCC.

Methods: Retrospective cohort study of patients in the National Cancer Database (NCDB) diagnosed with LSCC between January 2004 and December 2016 who underwent primary surgery.

Results: Seven thousand eight hundred and seventy-six patients met inclusion criteria. For cN0 patients, the rates of END and occult LNM both increased with tumor stage and were highest for supraglottic tumors. Predictors of occult LNM included supraglottic site, pathologic T3 and T4 stage, positive margins, and presence of lymphovascular invasion (p < 0.05).

Conclusions: The propensity for cervical LNM in surgically-managed LSCC varies based on primary tumor site and stage, and a variety of disease factors increase risk of occult LNM.

Keywords: head and neck; larynx cancer; metastasis; neck dissection; squamous cell carcinoma.

PubMed Disclaimer

References

REFERENCES

    1. Koroulakis A, Agarwal M. Laryngeal Cancer. StatPearls; 2022.
    1. Cramer JD, Burtness B, Le QT, Ferris RL. The changing therapeutic landscape of head and neck cancer. Nat Rev Clin Oncol. 2019;16(11):669-683.
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
    1. Leoncini E, Vukovic V, Cadoni G, et al. Clinical features and prognostic factors in patients with head and neck cancer: results from a multicentric study. Cancer Epidemiol. 2015;39(3):367-374.
    1. Cohen EE, LaMonte SJ, Erb NL, et al. American Cancer Society head and neck cancer survivorship care guideline. CA Cancer J Clin. 2016;66(3):203-239.

MeSH terms

LinkOut - more resources