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. 2023 Jun 24:5:100169.
doi: 10.1016/j.cccb.2023.100169. eCollection 2023.

Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion

Sanne Kuipers  1 , Sean W Willemse  1 , Jacoba P Greving  2 , Esther E Bron  3 , Robert J van Oostenbrugge  4 , Matthias J P van Osch  5 , Geert Jan Biessels  1 , L Jaap Kappelle  1 ; Heart-Brain Connection Consortium
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Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion

Sanne Kuipers et al. Cereb Circ Cogn Behav. .

Abstract

Background: Patients with carotid artery occlusion (CAO) are vulnerable to cognitive impairment (CI). Anaemia is associated with CI in the general population. We hypothesized that lower haemoglobin is associated with cognitive impairment (CI) in patients with CAO and that this association is accentuated by cerebral blood flow (CBF).

Methods: 104 patients (mean age 66±8 years, 77% men) with complete CAO from the Heart-Brain Connection study were included. Anaemia was defined as haemoglobin < 12 g/dL for women and < 13 g/dL for men. Cognitive test results were standardized into z-scores (using a reference group) in four cognitive domains. Patients were classified as cognitively impaired when ≥ one domain was impaired. The association between lower haemoglobin and both cognitive domain z-scores and the presence of CI was assessed with adjusted (age, sex, education and ischaemic stroke) regression models. Total CBF (measured with phase contrast MRI) and the interaction term haemoglobin*CBF were additionally added to the analyses.

Results: Anaemia was present in 6 (6%) patients and was associated with CI (RR 2.54, 95% CI 1.36; 4.76). Lower haemoglobin was associated with the presence of CI (RR per minus 1 g/dL haemoglobin 1.15, 95% CI 1.02; 1.30). This association was strongest for the attention-psychomotor speed domain (RR for impaired attention-psychomotor speed functioning per minus 1 g/dL haemoglobin 1.27, 95% CI 1.09;1.47) and ß for attention-psychomotor speed z-scores per minus 1 g/dL haemoglobin -0.19, 95% CI -0.33; -0.05). Adjustment for CBF did not affect these results and we found no interaction between haemoglobin and CBF in relation to cognition.

Conclusion: Lower haemoglobin concentrations are associated with CI in patients with complete CAO, particularly in the domain attention-psychomotor speed. CBF did not accentuate this association. If validated in longitudinal studies, haemoglobin might be a viable target to prevent cognitive deterioration in patients with CAO.

Keywords: Anaemia; Carotid artery occlusion; Cerebral blood flow; Cognition; Haemoglobin.

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Conflict of interest statement

M.J.P. van Osch receives research support from Philips.

Figures

Fig 1
Fig. 1
Association between haemoglobin concentration and attention-psychomotor speed functioning Legend: Plot showing the adjusted (for age, sex, education and history of ischaemic stroke) association between haemoglobin concentration (g/dL) and attention-psychomotor speed functioning (z-score), ß= 0.19, p-value <0.01.
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