Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug;45(8):975-987.
doi: 10.1007/s00276-023-03184-x. Epub 2023 Jul 5.

Structural and CBCT analysis of mandibular canal microvessels expressing neurotransmitters in human cadavers

Masachika Takiguchi  1 , Iwao Sato  2 , Yoko Ueda  1 , Shinichi Kawata  1 , Yutaro Natsuyama  1 , Tomiko Yakura  1 , Zhong-Lian Li  1 , Masahiro Itoh  1
Affiliations

Structural and CBCT analysis of mandibular canal microvessels expressing neurotransmitters in human cadavers

Masachika Takiguchi et al. Surg Radiol Anat. 2023 Aug.

Abstract

Purpose: This study focused on the detailed structure of microvessels of the neurotransmitter-positive vasa nervorum of the inferior alveolar nerve, vein, and artery in the mandibular canal (MC) to obtain information for improved safety in dental treatments. We also observed the detailed structure of the MC from the mental foramen to the mandibular foramen using cone-beam computed tomography (CBCT).

Methods: In this study, mandibles from 45 sides of 23 human cadavers aged 76-104 years were examined by microscopy, immunohistochemistry, and CBCT analysis. These data were further evaluated by principal component analysis (PCA).

Results: The microvessels of the vasa nervorum with calcitonin gene-related peptide- and neuropeptide Y-positive reactions were classified into 5 types: large (4.19%, 28/667); irregular large (7.35%, 49/667), numerous intermediate (29.23%, 195/667), irregular intermediate (29.23%, 195/667), and scattered fine (30.0%, 200/667) microvessels. The MC showed various structures from the 3rd molar to the premolars and was also classified into three types, including complete (57.0%, 228/400), partial (33.8%, 135/400), and unclear (9.2%, 37/400), from the mandibular foramen to the mental foramen. PCA results revealed that developed capillaries were mainly localized in the molar region.

Conclusions: Fine microvessels of the vasa nervorum expressing neurotransmitters are present from the molar to premolar region, which is key information for mandibular dental treatments. The different microvessel structures also indicate differences in specific characteristics between dentulous and edentulous cadavers regarding oral surgical and implant treatments.

Keywords: CBCT; CGRP; Mandibular canal; Microvessels; NPY.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Al OK, Salti L (2011) Postinsertion pain in region of mandibular dental implants: a case report. Implant Dent 20:27–31. https://doi.org/10.1097/ID.0b013e3182096c94 - DOI
    1. Anderson LC, Kosinski TF, Mentag PJ (1991) A review of the intraosseous course of the nerves of the mandible. J Oral Implantol 17:394–403 - PubMed
    1. Bar ZJ, Slasky BS (1997) CT imaging of mental nerve neuropathy: the numb chin syndrome. AJR Am J Roentgenol 168:371–376. https://doi.org/10.2214/ajr.168.2.9016210 - DOI
    1. Baraniuk JN, Kaliner MA (1990) Neuropeptides and nasal secretion. J Allergy Clin Immunol 86:620–627. https://doi.org/10.1016/s0091-6749(05)80226-x - DOI - PubMed
    1. Bjurholm A, Kreicbergs A, Terenius L, Goldstein M, Schultzberg M (1988) Neuropeptide Y-, tyrosine hydroxylase- and vasoactive intestinal polypeptide-immunoreactive nerves in bone and surrounding tissues. J Auton Nerv Syst 25:119–125. https://doi.org/10.1016/0165-1838(88)90016-1 - DOI - PubMed

LinkOut - more resources