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Review
. 2023 Jul 5;40(8):225.
doi: 10.1007/s12032-023-02101-x.

Impact of exosome therapy on pancreatic cancer and its progression

Mohamed El-Tanani  1   2   3 , Hamdi Nsairat  4 , Ismail I Matalka  5   6 , Alaa A A Aljabali  7 , Vijay Mishra  8 , Yachana Mishra  9 , Gowhar A Naikoo  10 , Sai Raghuveer Chava  11 , Nitin B Charbe  12 , Murtaza M Tambuwala  13
Affiliations
Review

Impact of exosome therapy on pancreatic cancer and its progression

Mohamed El-Tanani et al. Med Oncol. .

Abstract

Pancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. There are no imaging techniques or biomarkers that can accurately identify, categorize, or predict the biological behavior of this tumor. Exosomes are extracellular vesicles that play a crucial rule in the progression, metastasis, and chemoresistance of pancreatic cancer. They have been verified to be potential biomarkers for pancreatic cancer management. Studying the role of exosomes in pancreatic cancer is substantial. Exosomes are secreted by most eukaryotic cells and participated in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long non-coding RNA, circular RNA, etc., play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, in this concise review, we intend to summarize exosomes components and isolation, exosome secretion, function, importance of exosomes in the progression of pancreatic cancer and exosomal miRNAs as possible pancreatic cancer biomarkers. Finally, the application potential of exosomes in the treatment of pancreatic cancer, which provides theoretical supports for using exosomes to serve precise tumor treatment in the clinic, will be discussed.

Keywords: Biomarkers; Exosomes; Folfirinox; Gemcitabine; Intercellular communication; Pancreatic cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
A typical exosomes composition and structure of exosomes
Fig. 2
Fig. 2
Production and secretion of exosomes
Fig. 3
Fig. 3
Exosomes impact on pancreatic cancer progression
Fig. 4
Fig. 4
Exosomes in immunotherapy
See this image and copyright information in PMC

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