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. 2023 Jul 5;39(2):55-60.
doi: 10.21307/immunohematology-2023-009. eCollection 2023 Jun 1.

Significance of immunohematologic testing in mother and newborn ABO incompatibility

J Novoselac  1 , K Buzina Marić  2 , V Rimac  3 , I Selak  4 , M Raos  5 , B Golubić Ćepulić  5
Affiliations

Significance of immunohematologic testing in mother and newborn ABO incompatibility

J Novoselac et al. Immunohematology. .

Abstract

The aim of this study was to define risk factors for jaundice and anemia in newborns with a positive direct antiglobulin test (DAT) and/or with an incompatible crossmatch due to ABO incompatibility between mother and newborn. ABO incompatibility has become a more significant cause of hemolytic disease of the fetus and newborn since the introduction of effective anti-D prophylaxis. The condition is common and, if clinically significant at all, causes only mild jaundice, which can be treated with phototherapy (PT). However, rare and serious presentations, requiring transfusion therapy, have been noted. Clinical, laboratory, and immunohematologic data were collected retrospectively from medical records of ABO-incompatible newborns and their mothers over a 5-year period (2016-2020) from University Hospital Centre Zagreb. Two groups of newborns were compared: those who needed medical intervention because of hyperbilirubinemia or anemia and those who did not. Within the group of newborns requiring intervention, we also compared those with A and B blood groups. Over the 5-year period, 72 of 184 (39%) newborns required treatment. The treatment was PT in 71 (38%) newborns and erythrocyte transfusion in 2 (1%). In 112 (61%) newborns, ABO incompatibility was an accidental finding while performing blood group typing; these newborns did not require any therapy. In conclusion, we found a statistical, but not clinically significant, difference between the groups of treated and untreated newborns, related to the mode of delivery and DAT positivity within hours of delivery. There were no statistically significant differences in characteristics between the groups of treated newborns, except for two newborns with blood group A who received erythrocyte transfusions.

Keywords: ABO incompatibility; anemia; direct antiglobulin test; hemolytic disease of the fetus and newborn; jaundice.

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References

    1. Krog GR, Donneborg ML, Hansen BM, et al. Prediction of ABO hemolytic disease of the newborn using pre- and perinatal quantification of maternal anti-A/anti-B IgG titer. Pediatr Res 2021;90:74–81. doi: 10.1038/s41390-020-01232-5 - DOI
    1. Pegoraro V, Urbinati D, Visser GHA, et al. Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: a preventable disease that still produces significant morbidity and mortality in children. PLoS One 2020;15:7. doi: 10.1371/journal.pone.0235807 - DOI
    1. Klein HG, Anstee DJ. Mollison’s blood transfusion in clinical medicine. 11th ed. Hoboken, NJ: Wiley-Blackwell Publishing, 2005.
    1. Bennardello F, Coluzzi S, Curciarello G, et al. Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) and Italian Society of Gynaecology and Obstetrics (SIGO) working group: recommendations for the prevention and treatment of haemolytic disease of the foetus and newborn. Blood Transfus 2015;13:109–34. doi: 10.2450/2014.0119-14 - DOI
    1. Harmening DM. Modern blood banking and transfusion practices. 5th ed. Philadelphia, PA: F.A. Davis Company, 2005: 392.

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