Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 5;77(Suppl 1):S70-S74.
doi: 10.1093/cid/ciad224.

Using Colonization to Understand the Burden of Antimicrobial Resistance Across Low- and Middle-Income Countries

Affiliations

Using Colonization to Understand the Burden of Antimicrobial Resistance Across Low- and Middle-Income Countries

Ashley Styczynski et al. Clin Infect Dis. .

Abstract

Understanding the burden of antibiotic resistance globally is hindered by incomplete surveillance, particularly across low-resource settings. The Antibiotic Resistance in Communities and Hospitals (ARCH) consortium encompasses sites across 6 resource-limited settings and is intended to address these gaps. Supported by the Centers for Disease Control and Prevention, the ARCH studies seek to characterize the burden of antibiotic resistance by examining colonization prevalence at the community and hospital level and to evaluate for risk factors that are associated with colonization. In this supplement, 7 articles present results from these initial studies. Though future studies identifying and evaluating prevention strategies will be critical to mitigate spreading resistance and its impact on populations, the findings from these studies address important questions surrounding the epidemiology of antibiotic resistance.

Keywords: antibiotic resistance; colonization; epidemiologic trends; health outcomes.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

    1. Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 2022; 399:629–55. - PMC - PubMed
    1. Korach-Rechtman H, Hreish M, Fried C, et al. Intestinal dysbiosis in carriers of carbapenem-resistant Enterobacteriaceae. mSphere 2020; 5:e00173–20. - PMC - PubMed
    1. Vikesland P, Garner E, Gupta S, Kang S, Maile-Moskowitz A, Zhu N. Differential drivers of antimicrobial resistance across the world. Acc Chem Res 2019; 52: 916–24. - PubMed
    1. Sharma A, Luvsansharav U-O, Paul P, et al. Multi-country cross-sectional study of colonization with multidrug-resistant organisms: protocol and methods for the antibiotic resistance in communities and hospitals (ARCH) studies. BMC Public Health 2021; 21:1412. - PMC - PubMed
    1. Smith RM, Lautenbach E, Omulo S, et al. Human colonization with multidrug-resistant organisms: getting to the bottom of antibiotic resistance. Open Forum Infect Dis 2021; 8:ofab531. - PMC - PubMed

Substances