Effect of Peripherally Infused Norepinephrine on Reducing Central Venous Catheter Utilization

Sara M Powell^{1

2}, Andrew C Faust^{1

2}, Stephy George^{1

2}, Richard Townsend^{1

2}, Darla Eubank^{1

2}, Richard Kim^{1

2}

Affiliations

¹ Department of Pharmacy (Drs Powell, Faust, and George) and Infusion Support Team, Department of Nursing (Mr Townsend and Ms Eubank), Texas Health Presbyterian Hospital Dallas, Dallas, Texas; Sound Physician Group, Pulmonary/Critical Care Medicine, Dallas, Texas (Dr Kim).
² Sara M. Powell, PharmD, MS, is the current postgraduate year 2 Critical Care pharmacy resident at Texas Health Dallas, where she also completed her postgraduate year 1 Pharmacy Practice residency. She received her Master of Science degree in 2016 and Doctor of Pharmacy degree in 2021 from Texas Tech University Health Sciences Center in Lubbock, Texas. Dr Powell has research and practice interests in anticoagulant reversal, septic shock management, antimicrobial stewardship, and trauma. Andrew C. Faust, PharmD, BCPS, is the current medical intensive care unit clinical pharmacy specialist at Texas Health Dallas and has been in this role since 2011. He graduated pharmacy school from the University of Texas at Austin in 2009 and followed that with a postgraduate year 1 Pharmacy Practice residency at University Health in San Antonio, Texas, and a postgraduate year 2 Critical Care pharmacy residency at Methodist University Hospital in Memphis, Tennessee. Dr Faust has published multiple articles in the areas of critical care, anticoagulation, and infectious diseases and has interests in management of sepsis/shock, rationale antimicrobial use in critically ill patients, and sedation/analgesia management. Stephy George, PharmD, BCCCP, is the current emergency department (ED)/trauma clinical pharmacy specialist. She graduated from University of Houston College of Pharmacy in 2013 and completed her pharmacotherapy postgraduate year 1 at Methodist Hospital in San Antonio and Critical Care and postgraduate year 2 at North Texas VA/Texas Tech Health Science Center in Dallas before starting her career as a critical care pharmacy specialist in 2016. Her clinical areas of interest are multimodal pain management, ICU antimicrobial stewardship, and management of agitation in the ED. Richard Townsend, RN, has worked as a vascular access nurse at Texas Health Dallas since March of 2020. He graduated from nursing school in 2006 and has prior experience in intensive care nursing, emergency nursing as a medicine and trauma nurse, and in the cardiac catheterization laboratory. Darla Eubank, RN, received her Bachelor of Science in Nursing from Abilene Christian University in 1996. After graduation, she worked as a telemetry nurse, cardiac catheterization laboratory nurse, and progressive cardiac care unit charge nurse. She has been an infusion support nurse at Texas Health Dallas since 2003 and now serves as the charge nurse for the vascular access team. Ms Eubank has received an Impact Award from Texas Christian University for her work on an evidence-based project focused on midline use in difficult access patients. Richard Kim, MD, is a board-certified internal, pulmonary, and critical care medicine physician in Dallas, Texas. He completed internal medicine residency and a pulmonary and critical care medicine fellowship at the University of Louisville in 2020. He has particular interest in sepsis, point-of-care ultrasound, and pulmonary hypertension.

PMID: 37406335
DOI: 10.1097/NAN.0000000000000508

Effect of Peripherally Infused Norepinephrine on Reducing Central Venous Catheter Utilization

Sara M Powell et al. J Infus Nurs. 2023 Jul-Aug.

. 2023 Jul-Aug;46(4):210-216.

doi: 10.1097/NAN.0000000000000508.

Authors

Sara M Powell^{1

2}, Andrew C Faust^{1

2}, Stephy George^{1

2}, Richard Townsend^{1

2}, Darla Eubank^{1

2}, Richard Kim^{1

2}

Affiliations

¹ Department of Pharmacy (Drs Powell, Faust, and George) and Infusion Support Team, Department of Nursing (Mr Townsend and Ms Eubank), Texas Health Presbyterian Hospital Dallas, Dallas, Texas; Sound Physician Group, Pulmonary/Critical Care Medicine, Dallas, Texas (Dr Kim).
² Sara M. Powell, PharmD, MS, is the current postgraduate year 2 Critical Care pharmacy resident at Texas Health Dallas, where she also completed her postgraduate year 1 Pharmacy Practice residency. She received her Master of Science degree in 2016 and Doctor of Pharmacy degree in 2021 from Texas Tech University Health Sciences Center in Lubbock, Texas. Dr Powell has research and practice interests in anticoagulant reversal, septic shock management, antimicrobial stewardship, and trauma. Andrew C. Faust, PharmD, BCPS, is the current medical intensive care unit clinical pharmacy specialist at Texas Health Dallas and has been in this role since 2011. He graduated pharmacy school from the University of Texas at Austin in 2009 and followed that with a postgraduate year 1 Pharmacy Practice residency at University Health in San Antonio, Texas, and a postgraduate year 2 Critical Care pharmacy residency at Methodist University Hospital in Memphis, Tennessee. Dr Faust has published multiple articles in the areas of critical care, anticoagulation, and infectious diseases and has interests in management of sepsis/shock, rationale antimicrobial use in critically ill patients, and sedation/analgesia management. Stephy George, PharmD, BCCCP, is the current emergency department (ED)/trauma clinical pharmacy specialist. She graduated from University of Houston College of Pharmacy in 2013 and completed her pharmacotherapy postgraduate year 1 at Methodist Hospital in San Antonio and Critical Care and postgraduate year 2 at North Texas VA/Texas Tech Health Science Center in Dallas before starting her career as a critical care pharmacy specialist in 2016. Her clinical areas of interest are multimodal pain management, ICU antimicrobial stewardship, and management of agitation in the ED. Richard Townsend, RN, has worked as a vascular access nurse at Texas Health Dallas since March of 2020. He graduated from nursing school in 2006 and has prior experience in intensive care nursing, emergency nursing as a medicine and trauma nurse, and in the cardiac catheterization laboratory. Darla Eubank, RN, received her Bachelor of Science in Nursing from Abilene Christian University in 1996. After graduation, she worked as a telemetry nurse, cardiac catheterization laboratory nurse, and progressive cardiac care unit charge nurse. She has been an infusion support nurse at Texas Health Dallas since 2003 and now serves as the charge nurse for the vascular access team. Ms Eubank has received an Impact Award from Texas Christian University for her work on an evidence-based project focused on midline use in difficult access patients. Richard Kim, MD, is a board-certified internal, pulmonary, and critical care medicine physician in Dallas, Texas. He completed internal medicine residency and a pulmonary and critical care medicine fellowship at the University of Louisville in 2020. He has particular interest in sepsis, point-of-care ultrasound, and pulmonary hypertension.

PMID: 37406335
DOI: 10.1097/NAN.0000000000000508

Abstract

The purpose of this retrospective study was to evaluate the impact of peripherally administered norepinephrine on avoiding central venous catheter insertion while maintaining safety of the infusion. An institutional guideline allows peripheral infusion of norepinephrine via dedicated, 16- to 20-gauge, mid-to-upper arm intravenous (IV) catheters for up to 24 hours. The primary outcome was the need for central venous access in patients initially started on peripherally infused norepinephrine. A total of 124 patients were evaluated (98 initially on peripherally infused norepinephrine vs 26 with central catheter only administration). Thirty-six (37%) of the 98 patients who were started on peripheral norepinephrine avoided the need for central catheter placement, which was associated with $8,900 in direct supply cost avoidance. Eighty (82%) of the 98 patients who started peripherally infused norepinephrine required the vasopressor for ≤12 hours. No extravasation or local complications were observed in any of the 124 patients, regardless of site of infusion. Administration of norepinephrine via a dedicated peripheral IV site appears safe and may lead to a reduction in the need for subsequent central venous access. To achieve timely resuscitation goals, as well as to minimize complications associated with central access, initial peripheral administration should be considered for all patients.

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Conflict of interest statement

Disclosures: No relevant conflicts of interest to disclose.

References

1. Ong J, Van Gerpen R. Recommendations for the management of noncytotoxic vesicant extravasations. J Infus Nurs. 2020;43(6):319–343. doi:10.1097/NAN.0000000000000392
1. Plum M, Moukhachen O. Alternative pharmacological management of vasopressor extravasation in the absence of phentolamine. P T. 2017;42(9):581–592.
1. Gorski LA, Hadaway L, Hagle ME, et al. Infusion therapy standards of practice. J Infus Nurs. 2021;44(suppl 1):S1–S224. doi:10.1097/NAN.0000000000000396
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Effect of Peripherally Infused Norepinephrine on Reducing Central Venous Catheter Utilization

Affiliations

Effect of Peripherally Infused Norepinephrine on Reducing Central Venous Catheter Utilization

Authors

Affiliations

Abstract

Conflict of interest statement

References

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