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. 2023 Sep 15;208(6):733-736.
doi: 10.1164/rccm.202302-0340LE.

Distinct Genomic Landscape of Lung Adenocarcinoma from Household Use of Smoky Coal

Tongwu Zhang  1 , Phuc H Hoang  1 , Jason Y Y Wong  1 , Kaiyun Yang  2 , Kexin Chen  3 , Maria Pik Wong  4 , Roel C H Vermeulen  5 ; Xuanwei study team; Yunchao Huang  2 , Stephen J Chanock  1 , Nathaniel Rothman  1 , Qing Lan  1 , Maria Teresa Landi  1 ; Xuanwei study team members
Collaborators, Affiliations

Distinct Genomic Landscape of Lung Adenocarcinoma from Household Use of Smoky Coal

Tongwu Zhang et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Cosine similarity distributions between the mutational profiles of each sample or de novo signatures (SBS288A/DBS78A/ID83A in Xuanwei study only) and known polycyclic aromatic hydrocarbon–related signatures for SBS (left), DBS (middle) and ID (right) profiles. For the Xuanwei study, the tumor sample NALC-0015-T01, which had almost no exposure to smoky coal before age 18, is colored orange. A cosine similarity was used as a measure of closeness between two mutational patterns (profiles or signatures). This ranges between 0 and 1, where a similarity of 1 represents identical mutational patterns and a similarity of 0 represents completely different mutational patterns. 5-MC = 5-methylchrysene; BaP = benzo[a]pyrene; BPDE = benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; DBA = dibenz[a,h]anthracene; DBAC = dibenz(a,j)acridine; DBADE = dibenz[a,h]anthracene-3,4-diol-1,2-epoxide; DBP = dibenzo[a,l]pyrene; DBPDE = dibenzo[a,l]pyrene-11,12-dihydrodiol-13,14-epoxide; DBS = doublet base substitution; ID = insertions and deletions; SBS = single base substitution.
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References

    1. Lan Q, Chapman RS, Schreinemachers DM, Tian L, He X. Household stove improvement and risk of lung cancer in Xuanwei, China. J Natl Cancer Inst . 2002;94:826–835. - PubMed
    1. Barone-Adesi F, Chapman RS, Silverman DT, He X, Hu W, Vermeulen R, et al. Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study. BMJ . 2012;345:e5414. - PMC - PubMed
    1. Wong JYY, Downward GS, Hu W, Portengen L, Seow WJ, Silverman DT, et al. Lung cancer risk by geologic coal deposits: a case-control study of female never-smokers from Xuanwei and Fuyuan, China. Int J Cancer . 2019;144:2918–2927. - PMC - PubMed
    1. Vermeulen R, Downward GS, Zhang J, Hu W, Portengen L, Bassig BA, et al. Constituents of household air pollution and risk of lung cancer among never-smoking women in Xuanwei and Fuyuan, China. Environ Health Perspect . 2019;127:97001. - PMC - PubMed
    1. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature . 2020;578:82–93. - PMC - PubMed

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